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Characterization of the Hemolysin, Stachylysin, from Stachybotrys Chartarum

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Abstract:Stachybotrys chartarum is a toxigenic fungus that has been associated with human health concerns, including pulmonary hemorrhage/hemosiderosis. This fungus produces a hemolysin, stachylysin, which in its monomeric form, has a molecular wieght of 11,920 daltons as determined by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-MS). Heat treatment at 60oC for 30 min inactivated the protein. Stachylysin is composed of about 40% hydrophobic amino acids and contains 2 cysteine residues. Purified stachylysin requires more than 6 h to begin lysing sheep's red blood cells, but by 48 h the treated sheep's red blood cells show pores on the surface.
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Citation:Vesper, S. J., D. G. Dearborn, M. L. Magnuson, I. Yike, and R. A. Haugland. Characterization of the Hemolysin, Stachylysin, from Stachybotrys Chartarum. INFECTION AND IMMUNITY 69(2):912-916, (2001).
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Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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Division: Microbiological & Chemical Exposure Assessment Division
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Branch: Microbial Exposure Research Branch
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Product Type: Journal
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Published: 02/01/2001
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Related Entries:
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Bullet Item Risk Assessment/Risk Management for Indoor Mold
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
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