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Attempts to Establish Experimental Cyclospora Cayetanensis Infection in Laboratory Animals

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Abstract:Attempts were made to develop an animal model for Cyclospora cayetanensis to identify a practical laboratory host for studying human cyclosporiasis. Oocysts collected from stool of infected humans in the United States, Haiti, Guatemala, Peru and Nepal were held in potassium dichromate solution to allow development of sporozoites. The following animal types were inoculated: 9 strains of mice, including adult and neonatal immunocompetent and immune-deficient inbred and outbred strains, rats, sandrats, chickens, ducks, rabbits, gerbils, hamsters, ferrets, pigs, dogs, owl monkeys, rhesus monkeys and cynomolgus monkeys. Most animals were inoculated by gavage, although some of the primates were fed oocysts on food items. The animals were examined for signs of infection, particularly diarrhea, and stool samples were examined for 4-6 wk after inoculation. None of the animals developed patent infections or signs of infection. We conclude that none of the animals tested are susceptible to infection with C. cayetanensis.
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Citation:Eberhard, M. L., Y. R. Ortega, D. E. Hanes, E. K. Nace, R. Q. Do, M. G. Robl, K. Y. Won, C. Gavidia, N. L. Sass, K. Mansfield, A. Gozalo, J. Griffiths, R. Gilman, C. R. Sterling, and M. J. Arrowood. Attempts to Establish Experimental Cyclospora Cayetanensis Infection in Laboratory Animals.June 2000. JOURNAL OF PARASITOLOGY 86(3):577-582, (2000).
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Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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Division: Microbiological & Chemical Exposure Assessment Division
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Branch: Biohazard Assessment Research Branch
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Product Type: Journal
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Published: 06/01/2000
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Related Entries:
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Bullet Item Measure Occurrence and Exposure to Ccl-Related, Emerging and Regulated Waterborne Human Protozoa
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Last Updated on Monday, October 22, 2007
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