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Implications of Particulate Matter Research Program Upon Exposure Assessment and Apportionment and Attribution of Environmental Effects

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Abstract:Recent personal exposure panel studies and monitoring programs addressing fine particulate matter (PM) and associated co-pollutants have elucidated the physical and statistical relationships between personal exposures, residential indoor concentrations (and sources), concentrations immediately outside residences, and the ambient concentrations across the community. The data describe changes in potential exposures as a function of time (day, season), the subpopulation involved and their activities, the nature of the housing stock, and a variety of ambient variables. Secondly, a substantial number of clinical and epidemiological research efforts have established sufficient coherence between the toxicological and the epidemiological data as to provide a level of "biologic plausibility" to the observational studies: nonetheless, a number of hypotheses still remain as to which of the various PM characteristics are potentially significant contributors to the observed health effects. In addition, a great deal of measurement data on the concentrations, variability, and frequency of occurrence for a number of components, including potential agents of observable health effects, are now becoming available from large field campaigns and from operation of measurement networks. These data on concentrations, exposures, and health end points are reviewed and analyzed with regard to: the statistical relationships between the components or factors and the observed health end points; the physical and biological plausibility of those relationships; the apportionment of observable health effects to the various PM components, factors, and sources; the implications of the data for identifying the components and factors that could be associated with the observed epidemiological effects; and the implications for exposure measurements of particulate matter components, the associated co-pollutants, and hazardous air pollutants.

This is an abstract of a proposed presentation and does not necessarily reflect the United States Environmental Protection Agency (EPA) policy. The actual presentation has not been peer reviewed by EPA. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
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Citation:Cupitt, L. T. Implications of Particulate Matter Research Program Upon Exposure Assessment and Apportionment and Attribution of Environmental Effects. Presented at ISEA 2003 13th Annual Conference of the International Society of Exposure Analysis, Stresa, Italy, September 21-25, 2003.
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Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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Division: Office of the Director
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Branch: Immediate Office
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Product Type: Abstrct/Oral
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Presented: 09/21/2003
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