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Hesi Exposure Factors Database for Aggregate and Cumulative Risk Assessment

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Abstract: In recent years, the risk analysis community has broadened its use of complex aggregate and cumulative residential exposure models (e.g., to meet the requirements of the 1996 Food Quality Protection Act). The value of these models is their ability to incorporate a range of input variables in the overall estimation of total exposure and risk to an individual person with demographic, geographic and temporal specificity. However, a risk assessor's ability to evaluate the validity of a model outcome is predicated on a clear understanding of the quality and variability associated with these input variables. As such, the ILSI Health and Environmental Sciences Institute's (HESI) Risk Assessment Methodologies Technical Committee (RAM Committee) identified the need for better characterization and electronic availability of public, non-chemical specific data sets for use in state-of-the-science aggregate residential exposure models. As a first step, the RAM Committee, in conjunction with infoscientific.com, Inc., has reviewed public data on micro- and macro-activity activity factors (e.g., mouthing behavior event frequencies, time spent on a residential lawn), and mass-transfer-related factors (e.g., surface-to-skin/clothing mass transfer, biological monitoring measurements following choreographed dermal exposure events, dermal transfer coefficients, and transfer removal efficiencies). These data were evaluated both qualitatively and quantitatively and organized in an electronic database with their associated meta information. Additional data, meta information, and guidance can be added to this database in the future. Further, this effort provides important opportunities for collaboration and synergy with the EPA's Exposure Factors Handbook (general and child-specific) and regulatory agency exposure assessment methods development (e.g., EPA, Office of Pesticide Programs, Standard Operating Procedures for Residential Exposure Assessment). This database will be made publicly available and will assist risk assessors responsible for deterministic and probabilistic aggregate/cumulative residential risk analyses. The HESI RAM Technical Committee is composed of scientists from academia, industry, and government.

This work has been funded in part by the United States Protection Agency. It has been subjected to Agency review and approved for publication.
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Citation:Breckenridge, C., D. Sargent, J. Evans, K. R. Solomon, V. Zartarian, D. Vogel, W. D. Shade, J. Driver, M. Pandian, A. J. Goetz, S. Pettit, G. J. Mihlan, D. Miller, and J. Zabik. Hesi Exposure Factors Database for Aggregate and Cumulative Risk Assessment. Presented at Society for Risk Analysis Conference 2003, Baltimore, MD, December 7-10, 2003.
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure Modeling Research Branch
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Product Type: Abstrct/Oral
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Presented: 12/09/2003
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Related Entries:
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Bullet Item Next Generation Multimedia/Multipathway Exposure Modeling
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
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