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Levels of Chlorpyrifos and Its Degradation Product 3,5,6-Trichloro-2-Pyridinol in the Homes, Day Care Centers, and Urine of 130 North Carolina Preschool Children

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Abstract: This study examined the aggregate exposures of 257 preschool children to pollutants commonly found in their everyday environments. A primary objective was to identify important sources and routes that contribute to the children's exposures in these environments. Participants were recruited randomly from selected homes and day care centers in 12 North Carolina (NC) and Ohio counties. Monitoring was performed over a 48-hr period at the children's homes and/or day care centers. Samples that were collected included diet, water, air, urine, dust, soil, and surface wipes. The samples were analyzed by GC/MS for over 50 pollutants including chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol (TCP). Here we report preliminary results for levels of chlorpyrifos and TCP in multimedia samples collected at homes (n=130) or day care centers (n=13) of 130 NC preschool children. The median levels of chlorpyrifos and TCP measured at homes were 5.1 and 4.6 ng/sample (hand wipes), 6.1 and 1.9 ng/m3 (indoor air), 138.6 and 95.8 ng/g (dust), and 0.2 and 0.6 ng/g (soil), respectively. At day cares, the median levels of chlorpyrifos and TCP were 4.4 and 2.9 ng/sample (hand wipes), 3.2 and 0.9 ng/m3 (indoor air), 142.2 and 62.5 ng/g (dust), and 0.2 and 0.1 ng/g (soil), respectively. The median TCP concentration in the children's urine was 5.3 ng/mL. The results suggest that TCP may not be a useful urinary biomarker of exposure for children exposed to low levels of chlorpyrifos in their everyday environment.

This work has been funded wholly by the United States Environmental Protection Agency under contract #68-D-99-011 to Battelle. It has been subjected to Agency review and approved for publication.
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Citation:Morgan, M. K., L. S. Sheldon, N. K. Wilson, J. C. Chuang, C. Lyu, C. Croghan, G. L. Robertson, P. A. Jones, M. C. Brinkman, and R. C. Fortmann. Levels of Chlorpyrifos and Its Degradation Product 3,5,6-Trichloro-2-Pyridinol in the Homes, Day Care Centers, and Urine of 130 North Carolina Preschool Children. Presented at International Society of Exposure Analysis, Stresa, Italy, September 21-25, 2003.
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure Measurements & Analysis Branch
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Product Type: Abstrct/Oral
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Presented: 09/22/2003
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Related Entries:
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Bullet Item Children's Total Exposure to Persistent Pesticides and Other Persistent Organic Pollutants (Ctepp)
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
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