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Arsenic Speciation in Water and Dietary Samples By Ic-ICP-MS With Structural Verification Via Ic-Esi-MS/MS

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Abstract:The two predominate sources of arsenic exposure are water and dietary ingestion. Dietary sources can easily exceed drinking water exposures based on "total" arsenic measurements. This can be deceiving because arsenic's toxicity is strongly dependent on its chemical form and therefore, "total" arsenic measurements do not accurately reflect risk. The limited availability of species specific data in target foods induces a fair amount of uncertainty in the arsenic risk assessment. Thus, species specific data is essential for accurate risk assessment. The ability to quantitatively extract, separate and detect arsenicals from dietary sources has been the subject of numerous publications. Recently, our laboratory has been conducting research in a number of these areas including: 1) utilizing accelerated solvent extraction (ASE) as a potential semi-automated means to extract arsenicals from seafoods; 2) the effect of acidic and basic extraction solvents on the stability of certain arsenicals; 3) the bio-transformatoin of arsenosugars in synthetic stomach type environments; 4) improvement of extraction efficiencies in problrematic seafood matrices; and 5) preservation of AS(III) and number of analytical techniques including IC-ICP-MS and IC-ESI-MS-MS. This presentation will focus on the research highlights and some of the unique capabilities generated in order to better understand species specific stability.
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Citation:Creed, J. T., P. A. Gallagher, B. M. Gamble, A. Heck, and C. A. Schwegel. Arsenic Speciation in Water and Dietary Samples By Ic-ICP-MS With Structural Verification Via Ic-Esi-MS/MS. Presented at Federation of Analytical Chemistry and Spectroscopy Society Meeting, Detroit, MI, October 7-12, 2001.
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Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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Division: Microbiological & Chemical Exposure Assessment Division
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Branch: Chemical Exposure Research Branch
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Product Type: Abstrct/Oral
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Presented: 10/07/2001
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Related Entries:
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Bullet Item Estimating Bioavailability of Arsenicals in Dietary and Composite Diet Samples Via a Synthetic Stomach Extraction
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Last Updated on Monday, October 22, 2007
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