Skip common site navigation and headers
United States Environmental Protection Agency
Exposure Research
Begin Hierarchical Links EPA Home > Research & Development > Exposure Research > Publications/Presentations > End Hierarchical Links

 

Possible Role of Fungal Hemolysins in Sick Building Syndrome

spacer
spacer
Abstract:Many fungi produce proteinaceous hemolytic agents. Like bacterial hemolysins, fungal hemolysins create pores or holes in membranes. Depending on which membranes are damaged, fungal hemolysins can produce a variety of effects. Fungal hemolysins can cause histamine release from mast cells and/or induce cytokine release from human or animal cells. These responses may result in some of the flu- or cold-like syptoms associated with sick building syndrome (SBS). Fungal hemolysins, like bacterial hemolysins, can also damage vascular tissues and thus cause some SBS symptoms like headache, dizziness and bleeding. The source of fungal hemolysins may be the colonization of the airway, especially nasopharynx, by indoor fungi and not simply from the inhaled spores. Measurements of fungal hemolysins in serum or other bodily fluid should prove useful in diagnosing SBS.
spacer
Citation:Vesper, S. J. Possible Role of Fungal Hemolysins in Sick Building Syndrome. Presented at National Institute of Building Sciences Symposium: Mold, Moisture, Misery and Money plus Myth, San Diego, CA, October 30-31, 2004.
spacer
spacer
Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
spacer
Division: Microbiological & Chemical Exposure Assessment Division
spacer
Branch: Microbial Exposure Research Branch
spacer
Product Type: Abstrct/Oral
spacer
Presented: 10/30/2004
spacer
Related Entries:
spacer
Bullet Item Risk Assessment/Risk Management for Indoor Mold
spacer Relationship Reason:   A Project of the Product
spacer
spacer
spacer

 

ORD Home | Search EPA | Search NERL | Search EIMS | Contacts | Help

 
Begin Site Footer

EPA Home | Privacy and Security Notice | Contact Us

Last Updated on Monday, October 22, 2007
URL: http://cfpub.epa.gov