Skip common site navigation and headers
United States Environmental Protection Agency
Exposure Research
Begin Hierarchical Links EPA Home > Research & Development > Exposure Research > Publications/Presentations > End Hierarchical Links

 

Extraction and Detection of a New Arsine Sulfide Containing Arsenosugar in Molluscs By Ic-ICP-MS and Ic-Esi-MS/MS

spacer
spacer
Abstract:Using IC-ICP-MS and IC-ESI-MS/MS, an unknown arsenical compound in mollusks has been identified as a new arsine sulfide containing analog of a known arsenosugar and is referred to as As(498). This species has been observed in four separate shellfish species following a mild methanol/water extraction. As(498) is unstable, especially in acid, and converts to the arsine oxide containing arsenosugar As(482) over time.

Chromatographic retention of As(498) was observed on an anion exchanger ION-120 column but the species did not elute as a well defined peak from a PRP-X100. Mass spectrometric analysis of As(498) at pH 9.0 produced an [M-H]- species at a mass to charge of 497 in the negative-ion mode. A synthetic standard of As(498) was made by bubbling hydrogen sulfide into a stock solution of arsenosugar As(482). The retention time and ESI-MS/MS data were identical for the synthetic standard of As(498) and the unknown arsenical in s
spacer
Citation:Fricke, M., P. A. Creed, A. N. Parks, J. A. Shoemaker, C. A. Schwegel, and J. T. Creed. Extraction and Detection of a New Arsine Sulfide Containing Arsenosugar in Molluscs By Ic-ICP-MS and Ic-Esi-MS/MS. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 19(11):1454-1459, (2004).
spacer
spacer
Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
spacer
Division: Microbiological & Chemical Exposure Assessment Division
spacer
Branch: Chemical Exposure Research Branch
spacer
Product Type: Journal
spacer
Published: 11/01/2004
spacer
Downloads:
spacer
Bullet Item Extraction and Detection of a New Arsine Sulfide Containing Arsenosugar in Molluscs By Ic-ICP-MS and Ic-Esi-MS/MS
spacer
spacer
Related Entries:
spacer
Bullet Item Speciation of Arsenic in Dietary and Dietary Composite Samples to Provide a More Complete Assessment of Arsenic Exposure from Dietary Sources
spacer Relationship Reason:   A Project of the Product
spacer
Bullet Item Speciation of Arsenic in Dietary and Dietary Composite Samples to Provide a More Complete Assessment of Arsenic Exposure from Dietary Sources
spacer Relationship Reason:   A Project of the Product
spacer
spacer
spacer

 

ORD Home | Search EPA | Search NERL | Search EIMS | Contacts | Help

 
Begin Site Footer

EPA Home | Privacy and Security Notice | Contact Us

Last Updated on Monday, October 22, 2007
URL: http://cfpub.epa.gov