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Use of Pharmacokinetic Modeling to Design Studies for Pathway-Specific Exposure Model Evaluation

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Abstract:Validating an exposure pathway model is difficult because the biomarker, which is often used to evaluate the model prediction, is an integrated measure for exposures from all the exposure routes/pathways. The purpose of this paper is to demonstrate a method to use pharmacokenetic modeling and computer simulation to guide the design of field studies to validate pathway models. The children's dietary intake model was discussed in detail as an example. Three important aspects were identified for a successful design to evaluate the children's dietary intake model: (1) longitudinal design of the study with alternating exposure status for the route/pathway of interest; (2) short biological half-life of the selected chemical; and (3) surface loading of selected chemical at sufficient levels. Exposure from other pathways, such as inhalation and non-dietary ingestion exposure, would not mask the dietary exposure under normal circumstances. This study proposed and demonstrated the use of a pharmacokinetic model in the design of a study to evaluate a path-specific exposure model, which has not been explored previously.
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Citation:Hu, Y., G. G. Akland, E. D. Pellizzari, M. Berry, and L. J. Melnyk. Use of Pharmacokinetic Modeling to Design Studies for Pathway-Specific Exposure Model Evaluation. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 112(17):1697-1703, (2004).
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Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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Division: Microbiological & Chemical Exposure Assessment Division
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Branch: Chemical Exposure Research Branch
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Product Type: Journal
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Published: 12/01/2004
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Bullet Item Use of Pharmacokinetic Modeling to Design Studies for Pathway-Specific Exposure Model Evaluation
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Related Entries:
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Bullet Item Dietary Intake of Young Children
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Last Updated on Monday, October 22, 2007
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