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Hemolysin, Chrysolysin from Penicillium Chrysogenum Promotes Inflammatory Response

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Abstract:Some strains of Penicillium chrysogenum produce a proteinaceous hemolysin, chrysolysin, when incubated on sheep's blood agar at 37 �C but not at 23 �C. Chrysolysin is an aggregating protein composed of approximately 2 kDa monomers, contains one cysteine amino acid, and has an isoelectric point of 4.85. Treatment of murine macrophage cell line RAW 264.7 with purified chrysolin caused statistically significant (T-test, p<0.05) increased productionj of macrophage inflammatory protein-2 (MIP-2) in a dose dependent manner after 6 h treatment. This suggests that chrysolysin might act to promote the host's inflammatory response after P. chrysogenum exposures.
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Citation:Donohue, M. J., Y. Chung, M. L. Magnuson, M. W. Ward, M. K. Selgrade, and S. J. Vesper. Hemolysin, Chrysolysin from Penicillium Chrysogenum Promotes Inflammatory Response. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH. Urban & Fischer Verlag Jena, Jena, 208(4):279-285, (2005).
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Contact: Mary P. O'Bryant - (919)-541-4871 or obriant.mary@epa.gov
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Division: Microbiological & Chemical Exposure Assessment Division
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Branch: Microbial Exposure Research Branch
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Product Type: Journal
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Published: 07/01/2005
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Bullet Item Hemolysin, Chrysolysin from Penicillium Chrysogenum Promotes Inflammatory Response
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