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Roxarsone and Transformation Products in Chicken Manure: Determination By Capillary Electrophoresis-Inductively Couples Plasma Mass Spectromerty

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Abstract:The determination of the animal feed additive roxarsone (3-nitro-4- hydroxyphenylarsonic acid) and six of its possible transfonnation products (arsenite, arsenate, monomethylarsonate, dimethylarsinate, 3-amino-4-hydroxyphenylarsonic acid, and 4-hydroxyphenylarsonic acid) in chicken manure was investigated using capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICPMS). Initial method development was conducted using ultraviolet (UV) detection for ruggedness and time efficiency. Separation of these seven arsenic species was effected using a 20 mM phosphate buffer at pH 5.7. The CE-ICPMS limits of detection in terms of As for each of the species was in the low ugL-1 range, corresponding to absolute detection limits in the range 20-70 fg As (based on a 23-nL injection). Overall, the method developed in this study provides high selectivity and low limits of detection (1-3 ug L-1 or low-ppb, based on As), uses small sample volume (low nL), and produces minimal wastes.
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Citation:Rosal, C. G., G. M. Momplaisir, and E. M. Heithmar. Roxarsone and Transformation Products in Chicken Manure: Determination By Capillary Electrophoresis-Inductively Couples Plasma Mass Spectromerty. ELECTROPHORESIS. Wiley-VCH, Weinheim, 26(7-8):1606-1614, (2005).
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Contact: Chris Siebert - (702) 798-2234 or siebert.christopher@epa.gov
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Division: Environmental Sciences Division
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Branch: Environmental Chemistry Branch
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Product Type: Journal
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Published: 04/13/2005
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Bullet Item Roxarsone and Transformation Products in Chicken Manure
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Related Entries:
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Bullet Item Environmental Chemistry
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