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Quantification of 2,4-D on Solid-Phase Exposure Sampling Media By LC/MS/MS

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Abstract:Three types of solid phase chemical exposure sampling media: cellulose, polyurethane foam (PUF) and XAD-2, were analyzed for 2,4-D and the amine salts of 2,4-D. Individual samples were extracted into acidified methanol and the extracts were analyzed via LC/MS/MS using electrospray ionization and a C8 reversed-phase LC column. 13C 2,4-D and a labeled benzoic acid (13C or d5) were employed as the surrogate and internal standard respectively. Over a three year study of pesticide exposure among agricultural workers involving a high volume of analyses, values of average % recovery for 13C 2,4-D on personal exposure samples ranged from 87 to 98 with a % RSD ranging from 7 to 12. The performance of the method compares favorably with that of the current NIOSH recommended approach for the analysis of 2,4-D on these types of exposure sampling matrices.

The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under Contract 68-D-99-012 to RTI International. It has been subjected to Agency review, and approved for publication.
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Citation:Gardner, M., M. Spruillmccomb, J. Beach, L. Michael, K. W. Thomas, and R. Helburn. Quantification of 2,4-D on Solid-Phase Exposure Sampling Media By LC/MS/MS. JOURNAL OF ANALYTICAL TOXICOLOGY. Preston Publications Incorporated, Niles, IL, 29(3):188-192, (2005).
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure Measurements & Analysis Branch
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Product Type: Journal
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Published: 04/01/2005
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Downloads:
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Bullet Item Quantification of 2,4-D on Solid-Phase Exposure Sampling Media By LC/MS/MS
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