||Structure-Toxicity Relationships for alpha, beta-Unsaturated Alcohols in Fish.
Mckenyan, O. M.;
Veith, G. D.;
Bradbury, S. P.;
Russom., C. L.;
||Environmental Research Lab.-Duluth, MN. ;Wisconsin Univ.-Superior. Lake Superior Research Inst.
In vivo analysis;
In vitro analysis;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Previous toxicity testing with fathead minnows (Pimephales promelas) indicated that some unsaturated acetylenic and allylic alcohols can be metabolically activated, via alcohol dehydrogenase, to highly toxic alpha, Beta-unsaturated aldehydes and ketones or allene derivatives. Although several in vivo and in vitro toxicological and biochemical endpoints can differentiate these alcohols by toxic mechanism, the use of stereoelectronic molecular descriptors to discriminate these toxicants, and subsequently to predict potency, has not been previously attempted. Exploration of several descriptors indicated that soft electrophilic characteristics of acetylenic or allylic moieties in the suspected metabolites unambiguously discriminated reactive and narcotic toxicants. (Copyright (c) 1993 VCH Verlagsgesellschaft.)
||Pub. in Quant. Struct.-Act. Relat. v12 p132-136 1993. Prepared in cooperation with Wisconsin Univ.-Superior. Lake Superior Research Inst.
|NTIS Title Notes
||Reprint: Structure-Toxicity Relationships for alpha, beta-Unsaturated Alcohols in Fish.
||98F; 57B; 57Y; 57; 99B
||PC A02/MF A01