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RECORD NUMBER: 22 OF 31

Main Title Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals.
Author Veith, G. D.; Call, D. J.; Brooke, L. T.;
CORP Author Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.;Environmental Research Lab.-Duluth, MN.
Year Published 1983
Report Number EPA-R-809234; EPA-600/J-83-070;
Stock Number PB84-110006
Subjects Toxicology; Fishes; Lethal dosage; Mammals; Reprints; Fathead minnows; Pimephales promelas; Toxic substances; Water pollution effects(Animals)
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB84-110006 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. This nonspecific mode of toxic activity was found predominant in acute toxicity studies of industrial chemicals and fish. This paper presents 96-h LC50 values for 65 industrial chemicals including alcohols, ketones, ethers, alkyl halides, and substituted benzenes. The common mode of action permitted the development of a structure-toxicity relationship as follows: log LC50 = -0.94 log P + 0.94 log (0.000068P + 1) - 1.25 where P is the n-octanol/water partition coefficient. The data show that the toxicity of the chemicals to fish is directly comparable with the toxicity in mammals when expressed as chemical activity.
Availability Notes Pub. in Canadian Jnl. of Fisheries and Aquatic Science, v40 p743-748 1983.
NTIS Title Notes Journal article.
Title Annotations Reprint: Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals.
PUB Date Free Form c1983
Category Codes 6T; 6F; 57Y; 68D
NTIS Prices Not available NTIS
Primary Description 600/03
Document Type NT
Control Number 402046825
Cataloging Source NTIS/MT
Origin NTIS
Type CAT