| Main Title |
Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals. |
| Author |
Veith, G. D.;
Call, D. J.;
Brooke, L. T.;
|
| CORP Author |
Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.;Environmental Research Lab.-Duluth, MN. |
| Year Published |
1983 |
| Report Number |
EPA-R-809234; EPA-600/J-83-070; |
| Stock Number |
PB84-110006 |
| Subjects |
Toxicology;
Fishes;
Lethal dosage;
Mammals;
Reprints;
Fathead minnows;
Pimephales promelas;
Toxic substances;
Water pollution effects(Animals)
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB84-110006 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
06/23/1988 |
|
| Collation |
8p |
| Abstract |
Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. This nonspecific mode of toxic activity was found predominant in acute toxicity studies of industrial chemicals and fish. This paper presents 96-h LC50 values for 65 industrial chemicals including alcohols, ketones, ethers, alkyl halides, and substituted benzenes. The common mode of action permitted the development of a structure-toxicity relationship as follows: log LC50 = -0.94 log P + 0.94 log (0.000068P + 1) - 1.25 where P is the n-octanol/water partition coefficient. The data show that the toxicity of the chemicals to fish is directly comparable with the toxicity in mammals when expressed as chemical activity. |
| Availability Notes |
Pub. in Canadian Jnl. of Fisheries and Aquatic Science, v40 p743-748 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals. |
| PUB Date Free Form |
c1983 |
| Category Codes |
6T; 6F; 57Y; 68D |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/03 |
| Document Type |
NT |
| Control Number |
402046825 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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