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RECORD NUMBER: 21 OF 31

Main Title Estimating the Acute Toxicity of Narcotic Industrial Chemicals to Fathead Minnows.
Author Veith, G. D.; Call, D. J.; Brooke, L. T.;
CORP Author Environmental Research Lab.-Duluth, MN. ;Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.
Year Published 1984
Report Number EPA-600/D-84-190;
Stock Number PB84-224450
Subjects Toxicology; Narcotics; Estimates; Fishes; Screening; Fathead minnows; Toxic substances; Water pollution effects(Animals)
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB84-224450 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract The overwhelming number of industrial chemicals either in commerce or in development precludes actual toxicity testing of each chemical and creates a need for initial screening techniques to focus efforts on those chemicals with the greatest potential for adverse environmental effects. One promising screening technique is the use of the structure-activity relationship to estimate aquatic toxicity from chemical structure. Using five major classes of industrial chemicals from the Toxic Substances Control Act (TSCA) inventory, this paper presents a structure-activity relationship between the 96-h LC50 with fathead minnows and the n-octanol/water partition coefficient which can be computed from structure. Common industrial alcohols, ketones, alkyl halides, ethers, and benzenes are shown to cause lethality by the same mode of action of narcosis. Consequently, a single bilinear equation can predict adequately the 96-h LC50 of all classes of industrial chemicals to fathead minnows.
Supplementary Notes Prepared in cooperation with Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.
PUB Date Free Form Jul 84
Category Codes 6T; 6F; 57Y; 68D
NTIS Prices PC A02/MF A01
Primary Description 600/03
Document Type NT
Control Number 430023315
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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