OLS : Record

RECORD NUMBER: 2 OF 2

Main Title

Health Assessment Document for Acrylonitrile.

Author

Basu, D. K.; Hsu, R. S.; Neal, M. W.; Santodonato, J.; Sugatt, R. H.;

CORP Author

Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.

Year Published

1983

Report Number

EPA-600/8-82-007F;

Stock Number

PB84-149152

Subjects

Acrylonitriles; Toxicology; Nitriles; Physical properties; Chemical properties; Sampling; Sources; Residues; Transport; Distribution; Exposure; Concentration(Composition); Humans; Laboratory animals; Air quality; Analytical methods; Biological effects; Toxic substances

Internet Access

Description	Access URL
	http://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=3000170U.txt

Holdings

Library		Call Number	Additional Info	Location	Date Modified
NTIS		PB84-149152	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.	NTIS	06/23/1988

Collation

343p

Abstract

Acute acrylonitrile intoxication in humans, like many volatile organic compounds, results in irritation of the eyes and nose, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea, and convulsions. Unlike many of these other organics, acrylonitrile causes severe burns upon contact with the liquid chemical. Some significant functional disorders of the liver and kidney are observed under subchronic exposure conditions; while chronic exposure results in signs (unthrifty appearance, weight loss and early death) that may be related to the low food and water consumption resulting from the unpleasant taste of acrylonitrile in water. Pathological changes in rats believed to be treatment related include hyperplasia and hyperkeratosis of the squamous cells in the brain and mammary gland hyperplasia in females. The present data base from human and toxicologic studies provides enough evidence such that the International Agency for Research on Cancer (IARC) has characterized acrylonitrile as an animal carcinogen and a likely human carcinogen. Unlike the animal bioassay data, the human data base does not unequivocally demonstrate a causal association.

Supplementary Notes

OLS : Record

RECORD NUMBER: 2 OF 2

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