OLS : Record


Main Title Health Assessment Document for Acrylonitrile.
Author Basu, D. K.; Hsu, R. S.; Neal, M. W.; Santodonato, J.; Sugatt, R. H.;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Year Published 1983
Report Number EPA-600/8-82-007F;
Stock Number PB84-149152
Subjects Acrylonitriles; Toxicology; Nitriles; Physical properties; Chemical properties; Sampling; Sources; Residues; Transport; Distribution; Exposure; Concentration(Composition); Humans; Laboratory animals; Air quality; Analytical methods; Biological effects; Toxic substances
Internet Access
Description Access URL
Library   Call Number Additional Info Location Date Modified
NTIS PB84-149152 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 343p
Abstract Acute acrylonitrile intoxication in humans, like many volatile organic compounds, results in irritation of the eyes and nose, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea, and convulsions. Unlike many of these other organics, acrylonitrile causes severe burns upon contact with the liquid chemical. Some significant functional disorders of the liver and kidney are observed under subchronic exposure conditions; while chronic exposure results in signs (unthrifty appearance, weight loss and early death) that may be related to the low food and water consumption resulting from the unpleasant taste of acrylonitrile in water. Pathological changes in rats believed to be treatment related include hyperplasia and hyperkeratosis of the squamous cells in the brain and mammary gland hyperplasia in females. The present data base from human and toxicologic studies provides enough evidence such that the International Agency for Research on Cancer (IARC) has characterized acrylonitrile as an animal carcinogen and a likely human carcinogen. Unlike the animal bioassay data, the human data base does not unequivocally demonstrate a causal association.
Supplementary Notes See also PB83-129593.
NTIS Title Notes Final rept..
PUB Date Free Form Oct 83
Category Codes 6T; 6E; 57U#; 57Y; 68G#
NTIS Prices PC A15/MF A01
Primary Description 600/22
Document Type NT
Control Number 410422724
Cataloging Source NTIS/MT
Origin NTIS
Type CAT