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RECORD NUMBER: 4 OF 5

Main Title Influence of Crystallization Habit of Minerals on 'In Vitro' Cytotoxicity.
Author Palekar, Lalita D.; Spooner, Charles M.; Coffin, David L.;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;GCA Corp., Bedford, MA. GCA Technology Div.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1979
Report Number EPA-68-02-2566 ;EPA-68-02-2771; EPA-600/J-79-136;
Stock Number PB81-240830
Subjects Minerals; Toxicology; Cells(Biology); Hemolysis; In vitro analysis; Erythrocytes; Reprints; Cytotoxicity
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB81-240830 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 16p
Abstract Four samples of cummingtonite-grunerite series in various crystallization habits were tested in vitro. The cytotoxicity to Chinese hamster ovary cells and hemolysis to sheep erythrocytes was inversely proportional to the structural faults and surface defects of the minerals. At a comparable surface area, asbestiform grunerite (UICC amosite), semi-asbestiform cummingtonite, acicular cummingtonite, and acicular grunerite were found to be cytotoxic and hemolytic in a decreasing order. The influence of particle size on hemolysis and cytotoxicity was observed with acicular grunerite. Although samples of relatively large particle size were found to be inert, samples of smaller particle size were cytotoxic as well as hemolytic. No apparent relationship between surface charge and hemolysis as well as cytotoxicity was observed.
Supplementary Notes Pub. in Annals of the New York Academy of Sciences 330, p673-686 1979.
Title Annotations Reprint: Influence of Crystallization Habit of Minerals on 'In Vitro' Cytotoxicity,
PUB Date Free Form 14 Dec 79
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Control Number 323802943
Cataloging Source NTIS/MT
Origin NTIS
Type CAT