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RECORD NUMBER: 8 OF 44

Main Title Genetic Toxicology of Putative Nongenotoxic Carcinogens.
Author Jackson, M. A.; Stack, H. F.; Waters, M. D.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/094;
Stock Number PB93-175636
Subjects Toxicology; Carcinogens; Mutagenicity tests; Aneuploidy; Biological assays; Organic compounds; Chromosomal aberrations; Humans; Reprints; Genetic activity profile; Gene mutations; Putative nongenotoxic carcinogens; Short term tests
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB93-175636 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/23/1993
Collation 38p
Abstract The report examines a group of putative nongenotoxic carcinogens that have been cited in the published literature. Using short-term test data from the U.S. Environmental Protection Agency/International Agency for Research on Cancer genetic activity profile (EPA/IARC GAP) database, these agents are classified on the basis of their mutagenicity emphasizing three genetic endpoints: gene mutation, chromosomal aberration and aneuploidy. On the basis of results of short-term tests for these effects, criteria was defined for evidence of mutagenicity (and nonmutagenicity) these criteria were applied in classifying the group of putative nongenotoxic carcinogens. The results from this evaluation based on the EPA/IARC GAP database are presented along with a summary of the short-term test data for each chemical and the relevant carcinogenicity results from the NTP, Gene-Tox and IARC databases. The data clearly demonstrate that many of the putative nongenotoxic carcinogens that have been adequately tested in short-term bioassays induce gene or chromosomal mutations or aneuploidy. (Copyright (c) 1993 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Mutation Research, v296 n3 p241-277 1993. Sponsored by Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Genetic Toxicology of Putative Nongenotoxic Carcinogens.
Category Codes 57Y; 57F; 57B
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 316130708
Cataloging Source NTIS/MT
Origin NTIS
Type CAT