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RECORD NUMBER: 8 OF 44

Main Title Hazard Identification: Efficiency of Short-Term Tests in Identifying Germ Cell Mutagens and Putative Nongenotoxic Carcinogens.
Author Waters, M. D.; Stack, H. F.; Jackson, M. A.; Bridges., B. A.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Sussex Univ., Brighton (England). Cell Mutation Unit.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/208;
Stock Number PB94-163870
Subjects Mutagens; Carcinogens; Germ cells; Toxicity; Mutagenicity tests; Carcinogenicity tests; Humans; Bioassay; Chromosome aberrations; Micronucleus test; Aneuploidy; Reprint;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB94-163870 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 14p
Abstract For more than a decade, mutagenicity tests have had a clearly defined role in the identification of potential human mutagens and an ancillary role in the identification of potential human carcinogens. The efficiency of short-term tests in identifying germ cell mutagens has been examined using a combined data set derived from the U.S. Environmental Protection Agency/International Agency for Research on Cancer Genetic Activity Profile (EPA/IARC GAP) and EPA Gene-Tox databases. Our review of these data indicates adequate sensitivity of batteries of in vitro short-term mutagenicity tests in identifying germ cell mutagens. The analysis also supports the inclusion of an in vivo assay as suggested in proposed regulatory testing guidelines. In the context of carcinogenicity testing, the ability of short-term bioassays to detect genotoxic or mutagenic carcinogens is well established. Such tests are not considered to be as sensitive to nongenotoxic or nonmutagenic carcinogens. However, analyses presented in the report using the EPA/IARC GAP database demonstrate that many putative nongenotoxic carcinogens that have been adequately tested in short-term genetic bioassays induce gene or chromosomal mutation or aneuploidy. Further investigation should reveal whether the mutagenicity of these agents plays an important mechanistic role in their carcinogenicity.
Supplementary Notes Pub. in Environmental Health Perspectives Supplements, v101 sup3 p61-72 Oct 93. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. and Sussex Univ., Brighton (England). Cell Mutation Unit.
NTIS Title Notes Journal article.
Title Annotations Reprint: Hazard Identification: Efficiency of Short-Term Tests in Identifying Germ Cell Mutagens and Putative Nongenotoxic Carcinogens.
Category Codes 57Y; 57F; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 416823502
Cataloging Source NTIS/MT
Origin NTIS
Type CAT