OLS : Record


Main Title Concept of Activity Profiles of Antimutagens.
Author Waters, M. D.; Brady, A. L.; Stack, H. F.; Brockman, H. E.;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Illinois State Univ., Normal. Dept. of Biological Sciences.
Publisher 1 Aug 89
Year Published 1989
Report Number EPA/600/D-90/037;
Stock Number PB90-220781
Subjects Toxicology; Mutagens; Bioassay; Free radicals; Tables(Data); Salmonella typhimurium; Reprints; Mutagenicity tests; Carcinogenesis; Carcinogenicity tests; Mutagenicity tests
Library   Call Number Additional Info Location Date Modified
NTIS PB90-220781 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 20p
Abstract The paper will consider the use of short-term bioassays to identify antimutagenic and anticarcinogenic substances and to classify them according to the locus of their protective influence, i.e., intracellular or extracellular, and putative mechanism(s) of action. In the extracellular environment, inhibition of formation or uptake of mutagens and inactivation of promutagenic or mutagenic species are examples of antimutagenic mechanisms. Intracellularly, antimutagenic substances have been described as 'scavengers' of radicals, 'blocking agents' (involving at least 3 different mechanisms), and 'suppressing agents'. Additional intracellular mechanisms include alterations in DNA repair processes and/or modification of the genotoxic response to the mutagen/carcinogen. The presentation format will be based on the genetic activity profile (GAP) methodology developed by the authors. The GAPs of known mutagens/carcinogens will be presented together with newly designed profiles for antimutagens/anticarcinogens according to the classification scheme outlined above.
Supplementary Notes Pub. in Antimutagenesis and Anticarcinogenesis Mechanisms II, p87-104 Jan 90. See also PB90-112806. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Illinois State Univ., Normal. Dept. of Biological Sciences.
Title Annotations Reprint: Concept of Activity Profiles of Antimutagens.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 019413350
Cataloging Source NTIS/MT
Origin NTIS
Type CAT