OLS : Record


Main Title Genetic Toxicology of Benzoin and Caprolactam.
Author Brady, A. L.; Stack, H. F.; Waters, M. D.;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1989
Year Published 1989
Report Number EPA-68-02-4456; EPA/600/J-89/384;
Stock Number PB90-216151
Subjects Toxicology; Mutations; Bioassay; Tables(Data); Drosophila; Salmonella typhimurium; Saccharomyces; Reprints; Mutagenicity tests; Caprolactan; Benzoin; Transformed cell line
Library   Call Number Additional Info Location Date Modified
NTIS PB90-216151 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 15p
Abstract Based on animal carcinogenesis studies, benzoin and caprolactam have been classified as noncarcinogens. The genetic toxicity of both compounds has been thoroughly evaluated in short-term in vitro bioassays. Genetic activity profiles and corresponding data listings and summaries are presented for benzoin and caprolactam. Generally weak positive responses were obtained with benzoin only in mammalian cell mutagenesis and cell transformation assays. In the case of caprolactam, reproducible positive responses were obtained for somatic mutations in Drosophila and for mammalian cell transformation (in different cell lines) at high dose levels. Since the chemical structures of benzoin and caprolactam do not suggest the potential for genotoxicity, these responses may be associated with nonspecific toxicity. The overwhelming majority of short-term test data suggest that, in accordance with animal cancer data, benzoin and caprolactam are not genotoxic. (Copyright (c) Elsevier Science Publishers B. V. (Biomedical Division).)
Supplementary Notes Pub. in Mutation Research, v224 p391-403 Nov 89. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Genetic Toxicology of Benzoin and Caprolactam.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 018016102
Cataloging Source NTIS/MT
Origin NTIS
Type CAT