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RECORD NUMBER: 18 OF 57

Main Title Carcinogenic Effects of Acrylamide in Sencar and A/J Mice.
Author Bull, R. J.; Robinson, M.; Laurie, R. D.; Stoner, G. D.; Greisiger, E.;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo.
Year Published 1984
Report Number EPA/600/J-84/091;
Stock Number PB84-244060
Subjects Bioassay; Carcinogens; Pulmonary neoplasms; Lung; Environmental surveys; Mice; Laboratory animals; Mutagens; Salmonella; Bacteria; Air pollution; Reprints; Acrylamide; Air pollution effects(Animals); Carbamic acid/(ethyl-ester)
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB84-244060 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract Acrylamide structurally resembles vinyl carbamate, a proposed proximate carcinogenic form of ethyl carbamate. To test the hypothesis that acrylamide should possess carcinogenic properties, it was tested in the Salmonella-microsome assay for point mutation, as a skin tumor initiator in the Sencar mouse, and for its ability to induce lung adenomas in the A/J mouse. Acrylamide was found to be without activity as a mutagen in Salmonella strains TA 1535, TA 1537, TA 98, and TA 100 both in the presence and absence of rat liver microsomes using both the plate and liquid suspension assays. However, acrylamide was found to approximate ethyl carbamate in potency as a tumor initiator in the skin of the female Sencar mice. As with ethyl carbamate, acrylamide was more potent by systemic routes of administration relative to topical application. Acrylamide was also found to induce lung adenomas in male and female A/J mice using both the p.o. and i.p. routes of administration. Acrylamide was approximately one-seventh as potent as ethyl carbamate in the induction of lung adenomas. These data confirm the hypothesis that acrylamide possesses carcinogenic properties similar to ethyl carbamate.
Supplementary Notes Prepared in cooperation with Medical Coll. of Ohio at Toledo.
Availability Notes Pub. in Cancer Research 44, p107-111 Jan 84.
NTIS Title Notes Journal article.
Title Annotations Reprint: Carcinogenic Effects of Acrylamide in Sencar and A/J Mice.
PUB Date Free Form c1984
Category Codes 6T; 6E; 57Y; 57D; 68
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Control Number 435625566
Cataloging Source NTIS/MT
Origin NTIS
Type CAT