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RECORD NUMBER: 36 OF 57

Main Title Evaluation of the Teratogenic Effects of Tri-ortho-cresyl Phosphate in the Long-Evans Hooded Rat.
Author Tocco, D. R.; Randall, J. L.; York, R. G.; Smith, M. K.;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Cosen Technology, Inc., Dallas, TX.
Year Published 1987
Report Number EPA/600/J-87/091;
Stock Number PB88-125463
Subjects Toxicology; Congenital abnormalities; Nervous system disorders; Laboratory animals; Rats; Toxicity; Reprints; Tricresyl phosphates; Teratogens; Toxic substances
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB88-125463 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
Abstract The developmental toxicity of tri-ortho-cresyl phosphate (TOCP) was evaluated in Long-Evans rats. Pregnant rats were treated with 87.5, 175, and 350 mg/kg/day TOCP throughout organogenesis from gestation day 6 through 18 (day of sperm = day 0). The highest dose tested (350 mg/kg) was lethal in 28% of the dams; no maternal deaths or toxicity were observed in the 87.5 or 175 mg/kg dose groups. There were no significant differences noted among the experimental and control groups for preimplantation loss or resorption. Fetal weights for both sexes in the TOCP groups were significantly greater than in the control group; however, no difference among the TOCP groups was observed. Malformation rates were too low to warrant statistical analysis. Numerous soft tissue and skeletal variations were observed in both control and TOCP-treated groups; there were no significant differences in the frequency of variations among the dose groups. The results of the study indicate that TOCP is not teratogenic in the Long-Evans rat. (Copyright (c) 1987 Society of Toxicology.)
Supplementary Notes Pub. in Fundamental and Applied Toxicology, v8 n3 p291-297 Apr 87. Prepared in cooperation with Cosen Technology, Inc., Dallas, TX.
NTIS Title Notes Journal article.
Title Annotations Reprint: Evaluation of the Teratogenic Effects of Tri-ortho-cresyl Phosphate in the Long-Evans Hooded Rat.
PUB Date Free Form c1987
Category Codes 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Control Number 802919937
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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