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RECORD NUMBER: 3 OF 38

Main Title Some Implications of Toxicology and Pharmacokinetics for Exposure Assessment.
Author Cogliano, V. J.; Parker, J. C.;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher 1992
Year Published 1992
Report Number EPA/600/J-93/509;
Stock Number PB94-135142
Subjects Epidemiology; Public health; Carcinogens; Toxicity; Exposure; Hazardous materials; Risk; Health hazards; Drug kinetics; Dosage; Vinyl chloride; Age; Metabolism; Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB94-135142 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/14/1994
Collation 19p
Abstract In assessing adverse health risks from exposure to potential carcinogens, the usual practice is to use cumulative amount or total exposure received over a lifetime as the measure of dose unless there is evidence to the contrary. Different exposure regimens resulting in the same total dose are considered to be equivalent, and the assumption is made that a high dose of a carcinogen received over a short period of time is equivalent to a corresponding low dose spread over a lifetime. Vinyl chloride provides an example for which both toxicologic and pharmacokinetic evidence exists to counter this default assumption. These analyses suggest exposure information that would be useful in assessing health risks when substantial toxicologic and pharmacokinetic information is available.
Supplementary Notes Pub. in Jnl. of Exposure Analysis and Environmental Epidemiology, sup1 p189-207 1992.
NTIS Title Notes Journal article.
Title Annotations Reprint: Some Implications of Toxicology and Pharmacokinetics for Exposure Assessment.
Category Codes 68G; 57U; 57Y; 57Q
NTIS Prices PC A03/MF A01
Primary Description 600/21
Document Type NT
Control Number 406330741
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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