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Main Title Health assessment document for 1,2-dichloroethane (ethylene dichloride).
Author Davidson, I. W. F.; Parker, J. C.; Bosch, S.; Gray, D. A.; Santodonato, J.; Chen, C. W.; Miremath, C. B.
CORP Author United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Place Published Research Triangle Park, NC
Year Published 1985
Report Number EPA-600/8-84-006F
Stock Number PB86-122702
OCLC Number 12922195
Subjects Ethylene dichloride--Toxicology; Carcinogens; Hazardous materials; Industrial hygiene; Toxicology; Environmental surveys; Chlorine organic compounds; Assessments; Exposure; Mutagens; Laboratory animals; Chemical properties; Water pollution; Air pollution; Chemical analysis; Sampling; Sources; Transport properties; Ecology; Occupational safety and health; Toxic substances; Environmental health; Ethane/dichloro; Pharmacokinetics; Path of pollutants; Air pollution effects(Animals); Air pollution effects(Humans); Chemical industry; Public health; Urban areas; Industrial wastes; Soil analysis; Bioassays; Chloroethanes; Cancer; Land pollution
Subject Added Ent Ethylene dichloride--Toxicology.; Carcinogens.
Holdings
Library   Call Number Additional Info Location Date Modified
EIAD EPA-600/8-84-006F Region 2 Library/New York,NY 03/14/1998
EJAD EPA 600/8-84-006F Region 3 Library/Philadelphia, PA 12/10/1993
EJBD ARCHIVE EPA 600-8-84-006F Headquarters Library/Washington,DC 07/08/2013
EJBD EPA 600-8-84-006F c.1 Headquarters Library/Washington,DC 04/14/2014
EJED EPA 600-8-84-006F OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD EPA-600/8-84-006F Research Triangle Park Library/RTP, NC 03/19/2004
ELBD EPA-600/8-84-006F AWBERC Library/Cincinnati,OH 01/28/1989
EOAD EPA 600/8-84-006A 2 vols. Region 8 Technical Library/Denver,CO 05/24/2011
EOAD EPA 600/8-84-006F Region 8 Technical Library/Denver,CO 05/23/2011
ERAD EPA 600/8-84-006F Region 9 Library/San Francisco,CA 02/19/2013
ESAD EPA 600-8-84-006F Region 10 Library/Seattle,WA 03/23/2010
NTIS PB84-209865 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
NTIS PB86-122702 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 1 v. (various pagings) : ill. ; 28 cm.
Abstract Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indicate a concentration of equal to or less than 0.5 ppb for most locations. EDC is rapidly absorbed, metabolized, and eliminated. Unmetabolized EDC is eliminated almost exclusively via the lungs. In humans, the symptoms of acute toxicity from repeated exposures exceeding 60 ppm are irritation of the respiratory tract and eyes and CNS depression. According to available evidence EDC does not adversely affect the reproductive or development process in animals except at maternally toxic levels. Additional human epidemiologic studies are needed to establish conclusively that EDC is not a teratogen and does not cause adverse reproductive effects. Positive responses in different text systems indicate that EDC is a weak, direct-acting mutagen; however, several of its metabolites, formed in animals, are more potent mutagens than EDC. As a carcinogen, EDC induces tumors in rats and mice by various routes of exposure (gavage, intraperitoneally, dermally). However, lifetime inhalation exposure conditions did not produce tumors in rats or mice. Results from animal carcinogen studies, when considered with the positive evidence of mutagenicity and the presence of reactive metabolites and covalent bonding to DNA, suggest that EDC is a potential human carcinogen.
Notes "September 1985." "Final report." "EPA-600/8-84-006F." Includes bibliographical references.
Supplementary Notes See also PB84-209865.
Corporate Au Added Ent United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.
PUB Date Free Form 1985
Category Codes 6E; 6T; 6F; 6J; 68G; 57U; 57H; 57Y
NTIS Prices PC A17/MF A01
Primary Description 600/21
BIB Level m
Document Type BC
Control Number 425825217
OCLC Time Stamp 20140407125449
Cataloging Source OCLC/T
Language eng
Origin OCLC
Type MERGE
OCLC Rec Leader 01243cam 2200301Ia 45020