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RECORD NUMBER: 34 OF 58

Main Title Inhalation Studies of Mt. St. Helens Volcanic Ash in Animals. 1. Introduction and Exposure System.
Author Graham, J. A.; Miller, F. J.; Davies, D. W.; Hiteshew, M. E.; Walsh, L. C.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/128;
Stock Number PB86-100203
Subjects Toxicology; Volcanic ejecta; Deposition; Respiration; Rats; Laboratory animals; Reprints; Air pollution effects(Animals); Inhalation provocation tests
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB86-100203 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 12p
Abstract Due to the lack of information on the effects of inhaled Mt. St. Helens volcanic ash and its potential interaction with sulfur dioxide (SO2), animal studies were performed to determine the acute and chronic health effects of a short-term exposure. This paper describes the inhalation exposure system designed for these studies and theoretically compares the pulmonary deposition in the rats to that in humans. Considering the similarities and differences in regional pulmonary deposition in humans and animals, inhalation studies were performed with fine-mode (<2.5 um aerodynamic diameter, Dae) ash. Comparisons to coarse-mode (>2.5 um Dae) ash were made using intatracheal instillation. A whole-body exposure system was designed to provide inhalation exposures of animals to Mt. St. Helens volcanic ash. SO2, or a combination of both. All exposures were conducted using fine-mode ash samples generated by a Wright dust feed mechanism at a mean concentration of 9.4 mg/m3 (plus or minus) 1.0 SD. Sulfur dioxide was maintained at 2.5 mg/m3 (plus or minus) 0.13 SD. Scanning electron microscopy, X-ray diffraction, and X-ray fluorescence were used to characterize the ash. (Copyright (c) 1985, Academic Press, Inc.)
Supplementary Notes Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. See also PB86-100211.
Availability Notes Pub. in Environmental Research 37, n1 p61-71 Jun 85.
NTIS Title Notes Journal article.
Title Annotations Reprint: Inhalation Studies of Mt. St. Helens Volcanic Ash in Animals. 1. Introduction and Exposure System.
PUB Date Free Form c1985
Category Codes 6T; 6F; 8G; 57Y; 57H; 48F; 68A; 68G
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Control Number 533917075
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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