OLS : Record


Main Title Genotoxic activity of organic chemicals in drinking water microform /
Author Meier, J. R.
CORP Author Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Place Published Cincinnati, OH:
Year Published 1988
Report Number EPA/600/J-88/309
Stock Number PB89-202428
OCLC Number 44723281
Subjects Bacteria; Toxicity; Water treatment; Chlorination; Damage; Mutagens; Bioassay; Laboratory animals; Organic acids; Acidification; Carcinogens; Humans; Disinfection; Activated carbon treatment; Reprints; Drinking water; Organic chemicals
Library   Call Number Additional Info Location Date Modified
ERBD PB89-202428 NERL/ESD-LV Library/Las Vegas,NV 08/11/2000
NTIS PB89-202428 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 37 p. 28 cm.
Abstract The information summarized in the review provides substantial evidence for the widespread presence of genotoxins in drinking water. In many, if not most cases, the genotoxic activity can be directly attributed to the chlorination stage of drinking water treatment. The genotoxic activity appears to originate primarily from reactions of chlorine with humic substances in the source waters. Genotoxic activity in drinking water concentrates has been most frequently demonstrated using bacterial mutagenicity tests but results with mammalian cell assay systems are generally consistent with the findings from the bacterial assays. There is currently no evidence for genotoxic damage following in vivo exposures to animals. In some locations genotoxic contaminants of probable industrial and/or agricultural origin occur in the source waters and contribute substantially to the genotoxic activity of finished drinking waters. The method used for sample concentration can have an important bearing on study results. In particular, organic acids account for most of the mutagenicity of chlorinated drinking water, and their recovery from water requires an acidification step prior to extraction or XAD resin adsorption. Recently, one class of acidic compounds, the chlorinated hydroxyfuranones, has been shown to be responsible for a major part of the mutagenic activity.
Notes "Journal article." "EPA/600/J-88/309." "Published in Mutation Research, vol. 196, pp. 211-245, September 1988."
Supplementary Notes Pub. in Mutation Research, v196 p211-245 1988.
Corporate Au Added Ent United States. ; Health Effects Research Laboratory. Toxicology and Microbiology Division.
PUB Date Free Form 1988.
NTIS Prices PC A03/MF A01
BIB Level m
OCLC Time Stamp 20000804125956
Cataloging Source OCLC/T
Language eng
Origin OCLC
OCLC Rec Leader 01135nam 2200265Ka 45020