| Main Title |
Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity. |
| Author |
Johnson, K. B.;
Criwell, H. E.;
Jensen, K. F.;
Simson, P. E.;
Mueller, R. A.;
|
| CORP Author |
North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/375; |
| Stock Number |
PB93-107209 |
| Subjects |
Dopamine receptors;
Proto-oncogene proteins c-fos;
Pharmacology;
Oxidopamine;
Comparison;
Locomotion;
Rats;
Corpus striatum;
Immunohistochemistry;
Animal behavior;
Reprints;
SKF-38393;
A-68930
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB93-107209 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
06/08/1993 |
|
| Collation |
13p |
| Abstract |
Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound behavioral manifestations and induction of striatal c-fos-like immunoreactivity. The full D1-dopamine agonist l,(R,S)1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran hydrochloride (A-68930), like SKF-38393, produced a dose-dependent, D1-selective increase in locomotor activity and striatal c-fos-like immunoreactivity. These results with A-68930 provide additional evidence that the specific behavioral and biochemical responses observed in neonatally lesioned rats after SKF-38393 administration are due to actions on D1-dopamine receptors, and indicate that A-68930 provides a new tool for investigating D1-dopamine receptor function. |
| Supplementary Notes |
Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v262 n2 p855-865 Aug 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity. |
| Category Codes |
57Q; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Control Number |
234225638 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
![[logo] US EPA](http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}