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RECORD NUMBER: 3 OF 17

Main Title Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity.
Author Johnson, K. B.; Criwell, H. E.; Jensen, K. F.; Simson, P. E.; Mueller, R. A.;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/375;
Stock Number PB93-107209
Subjects Dopamine receptors; Proto-oncogene proteins c-fos; Pharmacology; Oxidopamine; Comparison; Locomotion; Rats; Corpus striatum; Immunohistochemistry; Animal behavior; Reprints; SKF-38393; A-68930
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB93-107209 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1993
Collation 13p
Abstract Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound behavioral manifestations and induction of striatal c-fos-like immunoreactivity. The full D1-dopamine agonist l,(R,S)1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran hydrochloride (A-68930), like SKF-38393, produced a dose-dependent, D1-selective increase in locomotor activity and striatal c-fos-like immunoreactivity. These results with A-68930 provide additional evidence that the specific behavioral and biochemical responses observed in neonatally lesioned rats after SKF-38393 administration are due to actions on D1-dopamine receptors, and indicate that A-68930 provides a new tool for investigating D1-dopamine receptor function.
Supplementary Notes Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v262 n2 p855-865 Aug 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity.
Category Codes 57Q; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 234225638
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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