OLS : Record

RECORD NUMBER: 34 OF 48

Main Title

Health assessment document for 1,2-dichloroethane (ethylene dichloride).

Author

Davidson, I. W. F.; Parker, J. C.; Bosch, S.; Gray, D. A.; Santodonato, J.; Chen, C. W.; Miremath, C. B.

CORP Author

United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.

Publisher

U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,

Place Published

Research Triangle Park, NC

Year Published

1985

Report Number

EPA-600/8-84-006F

Stock Number

PB86-122702

OCLC Number

12922195

Subjects

Ethylene dichloride--Toxicology; Carcinogens; Hazardous materials; Industrial hygiene; Toxicology; Environmental surveys; Chlorine organic compounds; Assessments; Exposure; Mutagens; Laboratory animals; Chemical properties; Water pollution; Air pollution; Chemical analysis; Sampling; Sources; Transport properties; Ecology; Occupational safety and health; Toxic substances; Environmental health; Ethane/dichloro; Pharmacokinetics; Path of pollutants; Air pollution effects(Animals); Air pollution effects(Humans); Chemical industry; Public health; Urban areas; Industrial wastes; Soil analysis; Bioassays; Chloroethanes; Cancer; Land pollution

Subject Added Ent

Ethylene dichloride--Toxicology.; Carcinogens.

Holdings

Library	Call Number	Additional Info	Location	Date Modified
EIAD	EPA-600/8-84-006F		Region 2 Library/New York,NY	03/14/1998
EJAD	EPA 600/8-84-006F		Region 3 Library/Philadelphia, PA	12/10/1993
EJED	EPA 600-8-84-006F		OCSPP Chemical Library/Washington,DC	01/01/1988
EKBD	EPA-600/8-84-006F		Research Triangle Park Library/RTP, NC	03/19/2004
ELBD	EPA-600/8-84-006F		AWBERC Library/Cincinnati,OH	01/28/1989
EOAD	EPA 600/8-84-006A	2 vols.	Region 8 Technical Library/Denver,CO	05/24/2011
EOAD	EPA 600/8-84-006F		Region 8 Technical Library/Denver,CO	05/23/2011
ERAD	EPA 600/8-84-006F		Region 9 Library/San Francisco,CA	02/19/2013
ESAD	EPA 600-8-84-006F		Region 10 Library/Seattle,WA	03/23/2010
NTIS	PB84-209865	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.	NTIS	06/23/1988
NTIS	PB86-122702	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.	NTIS	06/23/1988

Collation

1 v. (various pagings) : ill. ; 28 cm.

Abstract

Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indicate a concentration of equal to or less than 0.5 ppb for most locations. EDC is rapidly absorbed, metabolized, and eliminated. Unmetabolized EDC is eliminated almost exclusively via the lungs. In humans, the symptoms of acute toxicity from repeated exposures exceeding 60 ppm are irritation of the respiratory tract and eyes and CNS depression. According to available evidence EDC does not adversely affect the reproductive or development process in animals except at maternally toxic levels. Additional human epidemiologic studies are needed to establish conclusively that EDC is not a teratogen and does not cause adverse reproductive effects. Positive responses in different text systems indicate that EDC is a weak, direct-acting mutagen; however, several of its metabolites, formed in animals, are more potent mutagens than EDC. As a carcinogen, EDC induces tumors in rats and mice by various routes of exposure (gavage, intraperitoneally, dermally). However, lifetime inhalation exposure conditions did not produce tumors in rats or mice. Results from animal carcinogen studies, when considered with the positive evidence of mutagenicity and the presence of reactive metabolites and covalent bonding to DNA, suggest that EDC is a potential human carcinogen.

Notes

"April 1984." "External Review Draft." "EPA-600/8-84-006A." ; "September 1985." "Final report." "EPA-600/8-84-006F." Includes bibliographies.

Supplementary Notes

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RECORD NUMBER: 34 OF 48

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