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Main Title State-of-the-Science Workshop Report: Issues and Approaches in Low Dose-Response Extrapolationfor Environmental Health Risk Assessment.
Author R. H. WHITE; I. Cote; L. Zeise; M. FOX; F. Dominici
CORP Author Johns Hopkins Univ., Baltimore, MD. School of Public Health.; Environmental Protection Agency, Research Triangle Park, NC.; California Environmental Protection Agency, Sacramento. Office of Environmental Health Hazard Assessment.; Environmental Protection Agency, Washington, DC.; Clark Univ., Worcester, MA.
Year Published 2007
Stock Number PB2009-101838
Subjects Dose-response relationships; Low dose irradiation; Environmental exposure; Health effects; Meetings; Risk assessments; Extrapolation; Neoplasms; Radiation doses; Cancer; Environmental pollutants; Uncertainty; Variability; Evaluation; Statistical data
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB2009-101838 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 04/28/2010
Collation 31p
Abstract Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component of the risk assessment process. At a workshop held in Baltimore, MD, on April 23-24, 2007, and sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences and Public Policy Institute, a multidisciplinary group of experts reviewed the state of the science regarding low-dose extrapolation modeling and its application in environmental health risk assessments. Discussion topics were identified based on a literature review, which included examples for which human responses to ambient exposures have been extensively characterized for cancer and/or noncancer outcomes. Topics included: the need for formalized approaches and criteria to assess the evidence for mode of action; the use of human vs. animal data; the use of mode of action information in biologically-based models; and the implications of interindividual variability, background disease processes and background exposures in threshold vs. nonthreshold model choice.
Supplementary Notes Prepared in cooperation with Environmental Protection Agency, Research Triangle Park, NC., California Environmental Protection Agency, Sacramento. Office of Environmental Health Hazard Assessment., Environmental Protection Agency, Washington, DC. and Clark Univ., Worcester, MA.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Author Added Ent
T. A. Burke;
P. D. White;
D. B. Hattis;
J. M. Samet
PUB Date Free Form 2007
Category Codes 57V; 57E; 68G
NTIS Prices PC A04/MF A04
Document Type NT
Control Number 010500350
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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