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RECORD NUMBER: 2 OF 3

Main Title Interaction of Inorganic Mercury Salts with Model and Red Cell Membranes: Importance of Lipid Binding Sites.
Author Delnomdedieu, M.; Allis., J. W.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;French Foreign Ministry Lavoisier Program, Paris (France),
Publisher 1993
Year Published 1993
Report Number EPA/600/J-94/206;
Stock Number PB94-163854
Subjects Receptor sites(Physiology); Lipids; Mercury nitrates; Mercury chlorides; Membranes; Erythrocytes; Rats; Anisotropy; Temperature effects; Physicochemical properties; Heavy metals; Fluorescence; Concentration (Composition); pH; Models; Toxicity; Mercury inorganic compounds; Reprint; Model membranes; PS(Phosphatidylserine)
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB94-163854 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 19p
Abstract The effect of two mercury salts, HgCl2 and Hg(NO3)2, on the thermotropic properties of phosphatidylserine (PS) model membranes and sonicated rat red cell membranes was investigated by fluorescence polarization. Both Hg(II) salts abolished the phase transition and decreased the membrane fluidity by interacting with PS. These results indicate that besides protein thiol groups, Hg(II)-lipid binding sites play an important role in the interaction of Hg(II) with red cell membranes that is qualitatively different from Hg(II) binding to protein thiol groups. (Copyright (c) 1993 Elsevier Scientific Publishers Ireland Ltd.)
Supplementary Notes Pub. in Chemico-Biologic Interactions v88 n1 p71-87 Oct 93. Prepared in cooperation with French Foreign Ministry Lavoisier Program, Paris (France),.
NTIS Title Notes Journal article.
Title Annotations Reprint: Interaction of Inorganic Mercury Salts with Model and Red Cell Membranes: Importance of Lipid Binding Sites.
Category Codes 57Y; 57B; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 416823487
Cataloging Source NTIS/MT
Origin NTIS
Type CAT