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RECORD NUMBER: 36 OF 50

Main Title Mutagenicity of Nitrite-Treated Aqueous Extract of 'Piper betle'; L.
Author Chen, H. C.; Chang, Y. S.; Lee, T. C.;
CORP Author Rhode Island Univ., Kingston. ;National Taiwan Coll. of Marine Science and Technology, Keelung.;Environmental Research Lab., Narragansett, RI.
Year Published 1985
Report Number EPA/600/D-85/126;
Stock Number PB85-220408
Subjects Asia; Nitroso compounds; Toxicity; Betel quid; Carcinomas; Chewing; Mastication; Mutagens; Piper betle; Salmonella typhimurium; Piperidine/N-nitroso; Pyrrolidine/N-nitroso; Morpholine/N-nitroso; Epidemiologic methods
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB85-220408 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract Betel quid is chewed as a masticatory material by people in certain areas of Asia. The quid chewing has been related to oral cancer by epidemiological study. The mutagenic components in the aqueous extracts of betel quid ingredients were studied. Only nitrite-treated aqueous extract of Piper betle L fruits, leaves or rhizoma were demonstrated to exhibit a mutagenic response, using Salmonella typhimurium strains TA100 and TA1535 in the Ames test. When the aqueous extract of the fruit was nitrosated, the greatest number of mutagenic substances were formed at pH 3. The formation of mutagens was enhanced by increasing the temperature from 5 to 95 deg. C. Maximum production of the mutagens occurred within 15 min when nitrosation was conducted at 35 deg. C. The mutagenic components in nitrite-treated aqueous extract of Piper betle L fruit were found to be N-nitrosopiperidine, N-nitrosopyrrolidine, N-nitrosomorpholine, and other compounds, as determined by gas chromatography-thermal energy analyzer.
Supplementary Notes Prepared in cooperation with National Taiwan Coll. of Marine Science and Technology. Keelung.
Availability Notes Pub. in Proceedings of National Science Council (Taiwan), v8 n1 p4-10 Jan 84.
PUB Date Free Form c1985
Category Codes 6C; 6T; 6H; 57C; 57Y; 57L
NTIS Prices Not available NTIS
Primary Description 600/05
Document Type NT
Control Number 524127285
Cataloging Source NTIS/MT
Origin NTIS
Type CAT