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RECORD NUMBER: 30 OF 58

Main Title Effect of Lindane on Intestinal Nitroreductase, Azoreductase, SS-Glucuronidase, Dechlorinase, and Dehydrochlorinase Activity.
Author Chadwick, R. W.; Chang, J.; Forehand, L. R.; Long, J. E.; Duffy, M. C.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/346;
Stock Number PB91-163600
Subjects Lindane; Small intestine; Enzymology; Glucuronidase; Rats; Intestinal mucosa; Gas chromatography; Enterobacteriaceae; Reprints; Nitroreductase; Azoreductase; Dechlorinase; Dehydrochlorinase
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB91-163600 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 11p
Abstract The effect of daily p.o. injections of 20 mg/kg lindane on nitroreductase, azoreductase, B-glucuronidase, dechlorinase and dehydrochlorinase enzyme activity in the rat intestinal tract was investigated after 2 weeks and 5 weeks of treatment. Antibiotics were administered to half of the treated rats after 4 weeks of treatment. Results of the study indicated that lindane significantly increased nitro reductase and azoreductase activity in the small intestine, that there were regional differences in the effect of lindane as well as differences dependent on the exposure duration. The results also suggest the presence of substantial levels of mucosal enzyme in the small intestine.
Supplementary Notes Pub. in Pesticide Biochemistry and Physiology, v38 p48-56 Sep 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Lindane on Intestinal Nitroreductase, Azoreductase, SS-Glucuronidase, Dechlorinase, and Dehydrochlorinase Activity.
Category Codes 68E; 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 113027420
Cataloging Source NTIS/MT
Origin NTIS
Type CAT