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RECORD NUMBER: 6 OF 8

Main Title Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis.
Author Busch, R. H.; Lauhala, K. E.; Loscutoff, S. M.; McDonald, K. E.;
CORP Author Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/067;
Stock Number PB84-232685
Subjects Respiratory diseases; Emphysema; Pulmonary emphysema; Rats; Laboratory animals; Dosage; Toxicity; Reprints; Elastase; Morphogenesis
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB84-232685 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 19p
Abstract Emphysema was produced experimentally in rats by administration of porcine pancreatic elastase at dose levels of 75, 100, 125, and 150 units elastase activity/100 g body wt. All doses studied were equally effective in producing emphysema. Dose levels of over 75 units activity/100 g offered no advantage in terms of degree or severity of emphysema produced; however, such doses exacerbated hemorrhage and edema, resulting in relatively high post-instillation mortality. Lesion morphogenesis at all doses tested paralleled those described in this and in other species by other investigators. The 75-unit activity produced a quantifiable degree of emphysema which was relatively constant among animals. Results suggest that because of group differences in susceptibility to elastase (or variations in batches of elastase), dose-range studies should be performed on each new group of animals.
Availability Notes Pub. in Environmental Research 33, p497-513 1984.
NTIS Title Notes Journal article.
Title Annotations Reprint: Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis.
PUB Date Free Form c1984
Category Codes 6O; 6T; 57Q; 57Y
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Control Number 432820566
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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