| Main Title |
Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis. |
| Author |
Busch, R. H.;
Lauhala, K. E.;
Loscutoff, S. M.;
McDonald, K. E.;
|
| CORP Author |
Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/067; |
| Stock Number |
PB84-232685 |
| Subjects |
Respiratory diseases;
Emphysema;
Pulmonary emphysema;
Rats;
Laboratory animals;
Dosage;
Toxicity;
Reprints;
Elastase;
Morphogenesis
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB84-232685 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
06/23/1988 |
|
| Collation |
19p |
| Abstract |
Emphysema was produced experimentally in rats by administration of porcine pancreatic elastase at dose levels of 75, 100, 125, and 150 units elastase activity/100 g body wt. All doses studied were equally effective in producing emphysema. Dose levels of over 75 units activity/100 g offered no advantage in terms of degree or severity of emphysema produced; however, such doses exacerbated hemorrhage and edema, resulting in relatively high post-instillation mortality. Lesion morphogenesis at all doses tested paralleled those described in this and in other species by other investigators. The 75-unit activity produced a quantifiable degree of emphysema which was relatively constant among animals. Results suggest that because of group differences in susceptibility to elastase (or variations in batches of elastase), dose-range studies should be performed on each new group of animals. |
| Availability Notes |
Pub. in Environmental Research 33, p497-513 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis. |
| PUB Date Free Form |
c1984 |
| Category Codes |
6O; 6T; 57Q; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Control Number |
432820566 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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