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RECORD NUMBER: 4 OF 7

Main Title Effects of Ammonium Sulfate Aerosol Exposure on Lung Structure of Normal and Elastase-Impaired Rats and Guinea Pigs.
Author Busch, R. H.; Buschbom, R. L.; Cannon, W. C.; Lauhala, K. E.; Miller, F. J.;
CORP Author Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/068;
Stock Number PB84-233246
Subjects Ammonium; Lung; Emphysema; Rats; Guinea pigs; Laboratory animals; Aerosols; Morphology; Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB84-233246 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 22p
Abstract Rats and guinea pigs, pretreated with intratracheally administered elastase or saline, were exposed to 1.03 mg/cu. m.(NH4)2SO4. Identically treated controls were sham exposed. Measurements and evaluation of structural changes were conducted using morphometric techniques on SEM photographs and by applying subjective ratings. Pathology studies were conducted by light and electron microscopy. All examination methods confirmed elastase-induced emphysema, which was aggravated by (NH4)2SO4 exposure in the rat. Ammonium sulfate exposure of saline-treated animals produced measurable degrees of enlargement of alveoli, and alveolar ducts and sacs.
Availability Notes Pub. in Environmental Research 33, p454-472 1984.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Ammonium Sulfate Aerosol Exposure on Lung Structure of Normal and Elastase-Impaired Rats and Guinea Pigs.
PUB Date Free Form c1984
Category Codes 6T; 57Y
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Control Number 432821048
Cataloging Source NTIS/MT
Origin NTIS
Type CAT