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RECORD NUMBER: 48 OF 170

Main Title Carcinogenic Risk of Non-Uniform Alpha Particle Irradiation in the Lungs: Radon Progeny Effects at Bronchial Bifurcations.
Author Hoffmann, W.; Crawford-Brown, D. J.; Menache, M. G.; Martonen, T. B.;
CORP Author NSI Technology Services Corp., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Salzburg Univ. (Austria). Dept. of Biophysics.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/J-92/313;
Stock Number PB92-227545
Subjects Carcinogenesis; Radon; Bronchi; Pulmonary neoplasms; Alpha particles; Risk assessment; Dosimetry; Respiration; Air pollution effects(Humans); Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB92-227545 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 10p
Abstract The combined effect of enhanced deposition and reduced clearance at bronchial bifurcations leads to increased radon progeny doses within branching sites compared to uniformly distributed activity within a given airway generation. A multi-stage carcinogenesis model was used to predict the probability of lung cancer induction at different sites of the bronchial region. For relatively low radon progeny exposures, lung cancer risk is significantly higher in bifurcation zones, particularly at carinal ridges, than along tubular segments. At sufficiently high exposures, however, lung cancer risk is highest in the tubular portions of a generation. This suggests that the common assumption of a uniform dose distribution provides realistic risk estimates for high uranium miner exposures, but may underestimate lung cancer risk at low, environmental exposures. If concomitant exposure to cigarette smoke is factored into the risk analysis in a multiplicative fashion, then the effect related to risk inhomogeneity becomes even more pronounced.
Supplementary Notes Pub. in Radiation Protection Dosimetry, v38 n1-3 p91-98 Dec 91. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling, North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering, and Salzburg Univ. (Austria). Dept. of Biophysics. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Carcinogenic Risk of Non-Uniform Alpha Particle Irradiation in the Lungs: Radon Progeny Effects at Bronchial Bifurcations.
Category Codes 57V; 57E; 68A; 68F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 229734133
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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