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RECORD NUMBER: 2 OF 16

Main Title Genotoxicity in Mouse Lymphoma Cells of Chemicals Capable of Michael Addition.
Author Dearfield, K. L.; Harrington-Brock, K.; Doerr, C. L.; Rabinowitz, J. R.; Moore, M. M.;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA-68-02-4456; EPA/600/J-91/324;
Stock Number PB92-120484
Subjects Lymphoma; Mutagens; Toxic substances; Cultured tumor cells; Mutagenicity tests; Thymidine kinase; Metabolic activation; Mice; Acrylates; Sulfones; Reprints; Michael addition reaction
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB92-120484 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/24/1992
Collation 9p
Abstract Chemical agents that react via the Michael addition reaction have important industrial and consumer applications. Over the past several years, the authors have been evaluating the mutagenicity and clastogenicity of compounds capable of Michael-type reactions. These compounds, including acrylamide, several acrylate and methacrylate esters, vinyl sulfones, and phorone, have been evaluated using TK(+/-)-3.7.2C mouse lymphoma cells. Mutagenic chemicals induced increases in the number of small colony tk(-) deficient mutants. This suggested a clastogenic mechanism which was confirmed by demonstrating increases in aberrations and micronucleus frequencies in cultured cells. Vinyl sulfone was found to be the most effective chemical mutagen with induction of genotoxic effects at concentrations as low as 0.25 microgram/ml. The other compounds also produced positive results, but at higher concentrations.
Supplementary Notes Pub. in Mutagenesis, v6 n6 p519-525 Nov 91. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Genotoxicity in Mouse Lymphoma Cells of Chemicals Capable of Michael Addition.
Category Codes 68G; 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 203825584
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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