| Main Title |
Influence of Cytochrome P450 Mixed-Function Oxidase Induction on the Acute Toxicity to Rainbow Trout 'Salmo gairdner' of Primary Aromatic Amines. |
| Author |
Hermens, J. L. M.;
Bradbury, S. P.;
Broderius, S. J.;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. ;Utrecht Rijksuniversiteit (Netherlands). Research Inst. of Toxicology. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/391; |
| Stock Number |
PB91-171470 |
| Subjects |
Mixed function oxidases;
Trout;
Anilines;
Enzyme induction;
Polychlorobiphenyl compounds;
Benzopyrene;
Dose-response relationships;
Liver microsomes;
Metabolic activation;
Water pollution effects(Animals);
Reprints;
Cytochrome P-450
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB91-171470 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
09/04/1991 |
|
| Collation |
13p |
| Abstract |
The influence of enzyme induction on the acute toxicity of aniline and 4-chloroaniline to rainbow trout (Salmo gairdneri) was investigated. For these two xenobiotics, bioactivation reactions are known to occur in mammals. Induction of cytochrome P450 mixed-function oxidase was obtained by intraperitoneal (ip) injection of trout with a mixture of polychlorinated biphenyls (Aroclor 1254). Five days after ip injection with three different doses of Aroclor 1254 (50, 100, and 200 mg/kg), benzo(a)pyrene hydroxylase activity in trout liver microsomes increased five- to sixfold. Cytochrome P450 concentrations in the microsomes were slightly, but significantly, enhanced in two of the three dose levels. The 96-hr LC50's of aniline and 4-chloroaniline were not affected by pretreatment with Aroclor 1254, suggesting that metabolic activation does not necessarily play a role in the acute toxicity of aromatic amines to fish. (Copyright (c) 1990 Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Ecotoxicology and Environmental Safety, v20 p156-166 1990. Prepared in cooperation with Utrecht Rijksuniversiteit (Netherlands). Research Inst. of Toxicology. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Influence of Cytochrome P450 Mixed-Function Oxidase Induction on the Acute Toxicity to Rainbow Trout 'Salmo gairdner' of Primary Aromatic Amines. |
| Category Codes |
57Y; 57F; 68D |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Control Number |
116425948 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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