| Main Title |
Time-Course and Sensitivity of Muconic Acid as a Biomarker for Human Environmental Exposure to Benzene. |
| Author |
Buckley, T. J.;
Lindstrom, A. B.;
Highsmith, V. R.;
Bechtold, W. E.;
Sheldon, L. S.;
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Atmospheric Research and Exposure Assessment Lab. ;Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM. Inhalation Toxicology Research Inst. ;Research Triangle Inst., Research Triangle Park, NC. |
| Publisher |
1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/A-92/248; |
| Stock Number |
PB93-121044 |
| Subjects |
Benzene;
Biological markers;
Toxicology;
Environmental exposure;
Chemical water pollutants;
Humans;
Dose-response relationships;
Urine;
Muconic acids
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB93-121044 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
06/08/1993 |
|
| Collation |
8p |
| Abstract |
Preliminary results are presented that show the effect of increased benzene exposure on the urinary elimination of trans,trans-muconic acid (MA) for an adult male. The results were generated from a controlled exposure experiment whereby an individual was exposed to benzene during a shower with gasoline-contaminated ground water. Based on measured air and water concentrations, it is estimated that the 25 minute shower and drying-off exposure period resulted in an inhalation and dermal absorbed dose of 122 micrograms and 19 micrograms, respectively, yielding an average dose rate of 334 micrograms/h during the shower period. The measured background dose rate of 1.2 micrograms/h was exceeded by a factor of 278 during the shower exposure. The average urinary MA elimination rate increased from 3.7 micrograms/h during the 30 h period before the exposure to 17.9 micrograms/h during the 22 h period after the exposure. The post-exposure profile of muconic acid elimination (micrograms/h) was characterized by two minor peaks (47 and 35 micrograms/h) occurring within 3 h and a major peak (61 micrograms/h) at approximately 11 h. |
| Supplementary Notes |
Proceedings of the EPA/AWMA International Symposium: Measurement of Toxic and Related Air Pollutants, Durham, NC., May 3-8, 1992. Prepared in cooperation with Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM. Inhalation Toxicology Research Inst., and Research Triangle Inst., Research Triangle Park, NC. |
| Category Codes |
57Y; 57B; 68D |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/09 |
| Document Type |
NT |
| Control Number |
300826202 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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