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RECORD NUMBER: 3 OF 4

Main Title Development of In vivo Genotoxicity Tests in Estuarine Fish and Their Application to Aquatic Toxicology.
Author Means, J. C.; Daniels, C. B.; Baksi, S. M.;
CORP Author Louisiana State Univ., Baton Rouge. Inst. for Environmental Studies. ;Johns Hopkins Univ., Baltimore, MD. School of Hygiene and Public Health.;Environmental Research Lab., Narragansett, RI.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/463 ; ERLN-P06
Stock Number PB90-147695
Subjects Toxicology; Marine fishes; In vivo analysis; Cyclophosphamide; Exposure; Mutagens; Kidney; Liver; Gastrointestinal system; Estuaries; Reprints; Toxic substances; Mutagenicity tests; Aminoacridines; Ethyl methanesulfonate; N-methyl-n-nitro-n-nitroguanidine; Dose-response relationships
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB90-147695 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 7p
Abstract Genotoxicity assays were developed in embryonic stages of two species of fish, striped bass (Morone saxitilis) and sheepshead minnow (Cyprinodon variegatus), and in the adults of Fundulus heteroclitus using metaphase chromosome aberrations as the endpoint. Dose-dependent responses were obtained with several chemical mutagens, including 9-aminoacridine, ethylmethane sulphonate, cyclophosphamide and n-methyl-n-nitro-n-nitroguanidine, added to estuarine water at doses spanning several orders of magnitude in compound concentration. Exposures ranged from one to four days; however, two-day exposure time was found to be optimal in eggs and larvae. Tissues from the gills, kidney and intestinal tract of adult Fundulus were found to be responsive to mutagen exposure; however, the intestine gave the best responses. The results of these experiments suggest that these assays are sufficiently sensitive to be used in the field as well as in laboratory tests. (Copyright (c) 1988 Elsevier Applied Science Publishers, Ltd.)
Supplementary Notes Pub. in Marine Environmental Research, v24 p327-331 1988. Prepared in cooperation with Johns Hopkins Univ., Baltimore, MD. School of Hygiene and Public Health. Sponsored by Environmental Research Lab., Narragansett, RI.
NTIS Title Notes Journal article.
Title Annotations Reprint: Development of In vivo Genotoxicity Tests in Estuarine Fish and Their Application to Aquatic Toxicology.
Category Codes 57Y; 57F; 68D; 47D
NTIS Prices PC A02/MF A01
Primary Description 600/05
Document Type NT
Control Number 007531307
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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