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RECORD NUMBER: 27 OF 204

Main Title Maturational Changes in Dermal Absorption of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Fischer 344 Rats.
Author Anderson, Y. B.; Jackson, J. A.; Birnbaum, L. S.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/331;
Stock Number PB93-229490
Subjects Skin absorption; Toxicity; Tetrachlorodibenzodioxin; Rats; Tissue distribution; Feces; Body composition; Dose-response relationships; Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB93-229490 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 9p
Abstract Maturational changes in potential for systemic exposure to TCDD following dermal application of a low dose (200 pmol) of this chemical were examined in male Fischer 344 rats. Absorption, tissue distribution, and elimination of TCDD, measured as TCDD-derived radioactivity, were examined 72 hr after dermal application of 200 pmol ((3)H)TCDD (111 pmol/sq cm applied over 1.8 sq cm) to the interscapular region of 3-, 5-, 8-, 10-, and 36-week-old rats. Dermal absorption was greatest in 3-week-old rats, decreasing to approximately 80 pmol (approximately 40%) in 5-, 8-, and 10-week-old rats and to 45 pmol (approximately 22%) in 36-week-old rats. In each age group, 70 to 80% of the radioactivity remaining at the application site 72 hr after dosing could be removed with acetone swabs. Major tissue depots of radioactivity were liver and fat; skin and muscle were minor depots. Adipose tissue content (Y) increased linearly with body weight. (X),Y = 0.03X + 2.1 (R squared = 0.95). Results indicate that TCDD is absorbed to a greater degree through skin of very young animals and that a significant decrease in potential for systemic exposure may occur during maturation and again during aging.
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v119 n2 p214-220 Apr 93. Presented at the Annual Society of Toxicology Meeting, Miami Beach, FL., February 12-16, 1990. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Maturational Changes in Dermal Absorption of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Fischer 344 Rats.
Category Codes 57Y; 57S
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 328023491
Cataloging Source NTIS/MT
Origin NTIS
Type CAT