||Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene.
Selgrade, M. K.;
Daniels, M. J.;
Jaskot, R. H.;
Robinson, B. L.;
Allis, J. W.;
||Health Effects Research Lab., Research Triangle Park, NC. Immunotoxicology Branch. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Blood chemical analysis;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This study assessed effects of exposure to p-xylene, a ubiquitous air pollutant, on mice infected with murine cytomegalovirus (MCMV), a mouse model for a common human virus. Mice were exposed to filtered air, 600 or 1,200 ppm p-xylene 6 h/d for 4 d and infected with a sublethal dose of MCMV after the first exposure. No deaths occurred among uninfected, p-xylene-exposed mice or infected, air-exposed mice; 34% and 0% mortality occurred respectively in infected mice exposed to 1,200 and 600 ppm p-xylene. Virus titers in the liver and splenic natural killer cell activity were unaffected by exposure to 1,200 ppm p-xylene. MCMV significantly suppressed and p-xylene significantly increased total P-450 levels in the liver, but there was no significant interaction between the two Isozymes 1A1, 2B1/B2, and 2E1 were decreased to a similar degree, suggesting that the virus does not target specific isozymes. Enhanced mortality was not due to immune suppression. While p-xylene potentiated liver damage was caused by the virus, the magnitude of serum enzyme activities indicates that this damage was not a likely cause of death.
||Pub. in Jnl. of Toxicology and Environmental Health, v40 n1 p129-144 Sep 93. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene.
||57Y; 57K; 57F
||PC A03/MF A01