OLS : Record

RECORD NUMBER: 35 OF 230

Main Title

Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene.

Author

Selgrade, M. K.; Daniels, M. J.; Jaskot, R. H.; Robinson, B. L.; Allis, J. W.;

CORP Author

Health Effects Research Lab., Research Triangle Park, NC. Immunotoxicology Branch. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.

Publisher

c1993

Year Published

1993

Report Number

EPA/600/J-94/047;

Stock Number

PB94-137072

Subjects

Xylenes; Liver; Toxicity; Mortality; Virus diseases; Mice; Cytochrome P-450; Cytomegaloviruses; Aspartate aminotransferase; Alanine aminotransferase; Body weight; Organ weight; Lactate dehydrogenase; Isoenzymes; Blood chemical analysis; Reprints;

Holdings

Library		Call Number	Additional Info	Location	Date Modified
NTIS		PB94-137072	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.	NTIS	05/14/1994

Collation

18p

Abstract

This study assessed effects of exposure to p-xylene, a ubiquitous air pollutant, on mice infected with murine cytomegalovirus (MCMV), a mouse model for a common human virus. Mice were exposed to filtered air, 600 or 1,200 ppm p-xylene 6 h/d for 4 d and infected with a sublethal dose of MCMV after the first exposure. No deaths occurred among uninfected, p-xylene-exposed mice or infected, air-exposed mice; 34% and 0% mortality occurred respectively in infected mice exposed to 1,200 and 600 ppm p-xylene. Virus titers in the liver and splenic natural killer cell activity were unaffected by exposure to 1,200 ppm p-xylene. MCMV significantly suppressed and p-xylene significantly increased total P-450 levels in the liver, but there was no significant interaction between the two Isozymes 1A1, 2B1/B2, and 2E1 were decreased to a similar degree, suggesting that the virus does not target specific isozymes. Enhanced mortality was not due to immune suppression. While p-xylene potentiated liver damage was caused by the virus, the magnitude of serum enzyme activities indicates that this damage was not a likely cause of death.

Supplementary Notes

Pub. in Jnl. of Toxicology and Environmental Health, v40 n1 p129-144 Sep 93. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC.

NTIS Title Notes

Journal article.

Title Annotations

Reprint: Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene.

Category Codes

57Y; 57K; 57F

NTIS Prices

PC A03/MF A01

Primary Description

600/10

Document Type

Control Number

407719928

Cataloging Source

NTIS/MT

Origin

NTIS

Type

CAT

OLS : Record

RECORD NUMBER: 35 OF 230

Local Navigation