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RECORD NUMBER: 39 OF 121

Main Title Effect of Flavanone on Mixed-Function Oxidase and Conjugation Reactions in Rats (Journal Version).
Author Trela, B. A.; Carlson, G. P.;
CORP Author Purdue Univ., Lafayette, IN.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/408;
Stock Number PB89-105548
Subjects Xenobiotics; Enzyme induction; Mixed function oxidases; Glutathime trasferases; Glucuronyltransferase; Liver; Laboratory animals; Oxygen heterocyclic compounds; Toxicity; Reprints; Flavanone
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB89-105548 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 7p
Abstract Flavanone administered to female Fischer 344 rats at doses up to 1.00 mmol/kg/day for seven days did not induce ethylmorphine demethylation, aniline hydroxylation, hexobarbital oxidation or aldrin epoxidation. Flavanone administered at a dose of 0.05 mmol/kg/day for seven days increased glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy)propane as substrates, and increased the glucuronidation of 1-naphthol and at 0.20 mmol/kg the glucuronidation of chloramphenicol. Flavanone administration did not alter sulfotransferase activity with 2-naphthol as the substrate, or enhance glutathione-S-transferase or glucuronyltransferase activity when added in vitro.
Supplementary Notes Pub. in Xenobiotica, v17 n1 p11-16 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Flavanone on Mixed-Function Oxidase and Conjugation Reactions in Rats (Journal Version).
Category Codes 57B; 57Y
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Control Number 833027478
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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