| Main Title |
Effect of Flavanone on Mixed-Function Oxidase and Conjugation Reactions in Rats (Journal Version). |
| Author |
Trela, B. A.;
Carlson, G. P.;
|
| CORP Author |
Purdue Univ., Lafayette, IN.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/408; |
| Stock Number |
PB89-105548 |
| Subjects |
Xenobiotics;
Enzyme induction;
Mixed function oxidases;
Glutathime trasferases;
Glucuronyltransferase;
Liver;
Laboratory animals;
Oxygen heterocyclic compounds;
Toxicity;
Reprints;
Flavanone
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB89-105548 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
03/14/1989 |
|
| Collation |
7p |
| Abstract |
Flavanone administered to female Fischer 344 rats at doses up to 1.00 mmol/kg/day for seven days did not induce ethylmorphine demethylation, aniline hydroxylation, hexobarbital oxidation or aldrin epoxidation. Flavanone administered at a dose of 0.05 mmol/kg/day for seven days increased glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy)propane as substrates, and increased the glucuronidation of 1-naphthol and at 0.20 mmol/kg the glucuronidation of chloramphenicol. Flavanone administration did not alter sulfotransferase activity with 2-naphthol as the substrate, or enhance glutathione-S-transferase or glucuronyltransferase activity when added in vitro. |
| Supplementary Notes |
Pub. in Xenobiotica, v17 n1 p11-16 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Flavanone on Mixed-Function Oxidase and Conjugation Reactions in Rats (Journal Version). |
| Category Codes |
57B; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Control Number |
833027478 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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