OLS : Record

RECORD NUMBER: 7 OF 689

Main Title 2 Phenoxyethanol: Two-week Dermal Probe Study in Female New Zealand White Rabbits to Assess Hematological Effects with Cover Letter.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1985
Report Number 878216053
Stock Number OTS0206805
Subjects Toxicology; Health effects; 2-phenoxyethanol (122-99-6); Subchronic Toxicity; Mammals; Rabbits; Dermal; Toxic substances; Laboratory animals; CAS No 122-99-6
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS OTS0206805 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 22p
Abstract Subchronic toxicity was evaluated in groups of 10 female New Zealand White rabbits exposed to 2-phenoxyethanol for 14 consecutive days at a level of 0 or 0.91 ml/kg/day as an occluded dose to clipped, intact skin. Mortality was observed in 7 rabbits by day 8 of the experiment. Clinical observations included discoloration of the skin at the test site. Necropsy revealed hemoglobinuria; pale livers; dark kidneys and spleens; decreased hemoglobin, PCV and RBC values; increased erythrocyte indices, nucleated RBC's, leukocytes and erythrocytes; and regenerative hemolytic anemia due to intravascular hemolysis of RBC's.
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PUB Date Free Form 1985
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A03/MF A03
Document Type NT
Control Number 028801100
Cataloging Source NTIS/MT
Origin NTIS
Type CAT