OLS : Record

RECORD NUMBER: 14 OF 275

Main Title Acute Skin Irritation Study of Hexamethyldisiloxane in Albino Rabbits with Cover Letter dated 04/20/94.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 8EHQ-86940001784
Stock Number OTS0572296
Subjects Toxicology; Health effects; Hexamethyldisiloxane; Toxicity; Primary dermal irritation; Mammals; Rabbits; Dermal; CAS No 107-46-0; Toxic substances; Laboratory animals
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS OTS0572296 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 15p
Abstract An acute dermal irritation study was conducted to assess the skin irritation potential of methyl disiloxane in male New Zealand white rabbits. The test material (0.5 ml) was applied uniformly to two intact, shaved test sites on the dorsal side of 12 male rabbits. The test site was then covered with a semiocculsive covering. Adjacent areas of untreated skin served as the control. The test animals were observed for signs of toxicity, mortality, and general activity. The application sites from groups of 4 animals were examined at 1, 2, 4, 8, 16, and 24 hours post-exposure. Skin irritation scores for erythema, edema, and other evidence of irritation were noted for all animals. No skin irritation was observed in any of the animals at any of the time points examined. In addition, no obvious effects on body weight gain, food consumption, survival, or animal behavior were observed. This assessment indicates methyl disiloxane did not produce dermal irritation or other observable signs of toxicity.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
PUB Date Free Form 1994
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A03/MF A03
Document Type NT
Control Number 028804050
Cataloging Source NTIS/MT
Origin NTIS
Type CAT