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RECORD NUMBER: 36 OF 119

Main Title Effects of the Herbicide 2,4-Dichlorophenyl(rho)-Nitrophenyl Ether (NIT) on Serum Thyroid Hormones in Adult Female Mice.
Author Gray jr, L. E.; Kavlock, R. J.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83-044;
Stock Number PB84-101500
Subjects Herbicides; Thyroid hormones; Hormones; Females; Mice; Parenteral infusions; Dosage; Nitrogen organic compounds; Reprints; Nitrogen; Ether/(dichlorophenyl)-(nitrophenyl)
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB84-101500 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract The administration of the herbicide 2,4-Dichlorophenyl-p-nitrophenyl ether (nitrofen; NIT) to adult female mice by i.p. injection at doses of 500 and 1000 mg/kg/day for 3 days, reduced serum thyroxine (T4) levels. T4 levels were reduced in the high-dosage group by 60% of the control and by 20% in the low-dose group. Serum triiodothyronine (T3) levels were relatively unaffected by NIT treatment at either dose. The animals appeared euthyoid, as body weights were unaffected even though T4 levels were reduced. Liver weights were slightly higher as a result of NIT exposure at both 500 and 1000 mg/kg/day.
Supplementary Notes Pub. in Toxicology Letters, 15 p231-235 1983.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of the Herbicide 2,4-Dichlorophenyl(rho)-Nitrophenyl Ether (NIT) on Serum Thyroid Hormones in Adult Female Mice.
PUB Date Free Form 1983
Category Codes 6T; 6F; 57Y; 68E
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Control Number 400621350
Cataloging Source NTIS/MT
Origin NTIS
Type CAT