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OLS : Record

RECORD NUMBER: 23 OF 522

Main Title Acute Oral Administration of Benzotriazole to Rats with Cover Letter Dated 06/12/1989.
CORP Author Sherwin-Williams Co., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1989
Report Number 86-890000592
Stock Number OTS0520631
Subjects Toxicology; Health effects; Benzatriazole (95-14-7); Acute Toxicity; Mammals; Rats; Oral; Gavage; Toxic substances; Laboratory animals; CAS No 95-14-7
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS OTS0520631 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 9p
Abstract Acute oral toxicity was evaluated in groups of 5 male albino Greenacres rats administered, by gavage, benzotriazole at dose levels of 46.4, 100 and 215 mg/kg in a 10% (w/v) suspension, or 464, 1000 and 2150 mg/kg in a 50% suspension. Mortality was observed within 14 days of dosing (4 rats each in the 1000 and 2150 mg/kg). No mortalities were observed at any dose level of the 10% suspension. The oral LD50 was 909 mg/kg (95% confidence limit = 546 to 1510 mg/kg). Clinical observations included depressed righting and placement reflexes among animals of the 46.4, 100 and 215 mg/kg dose groups. At high dose levels, observations included depressed righting and placement reflexes, absence of pain, shallow respiration, followed by death. Gross necropsy revealed paled extremities, slight to moderate congestion of lungs, kidneys and adrenals, and slight irritation of the small intestines.
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PUB Date Free Form 1989
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A02/MF A02
Document Type NT
Control Number 028807820
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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