OLS : Record

RECORD NUMBER: 17 OF 2149

Main Title 14-day Subchronic Oral Gavage Study with Octamethylcyclotetrasiloxane in Rats.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1990
Report Number 86-910000037
Stock Number OTS0528331
Subjects Toxicology; Health effects; Octamethylcyclotetrasiloxane (556-67-2); Subchronic Toxicity; Mammals; Rats; Oral; Gavage; Toxic substances; Laboratory animals; CAS No 556-67-2
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS OTS0528331 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 46p
Abstract This study evaluated potential subacute effects associated with Dimethylcyclosiloxane Fluid. Five groups of 8 female and 8 male Charles River CD Sprague Dawley rats were administered 25, 100, 400, or 1600 mg/kg/day of the test substance via oral gavage 5 days a week for 2 weeks. One group was given 4 ml/kg of a 0.5% suspension of Methocel A4M and distilled water and served as the vehicle control. The animals were observed daily on week days for signs of toxicity, general appearance, behavioral abnormalities, signs of local or systemic toxicity, and mortality. On weekends the animals were observed for mortality. Body weights were recorded prior to the sixth dose for recalculation of the dosages, and at necropsy. Gross necropsy was performed on all animals. No significant signs of toxicity or behavioral changes were seen in any of the animals. Group mean terminal body weights were statistically significantly lower in the high dose group male and females when compared to the controls. Male and female animals in the 400 and 1600 mg/kg/day groups showed statistically significant increases in group mean relative liver weights. Female group mean liver weights were also significantly increased in the 100 mg/kg/day group. Absolute liver weights were significantly increased in the 400 and 1600 mg/kg/day females. A significant trend was observed through the lowest male and female dose group. Doses of 100, 400, and 1600 mg/kg/day of Dimethylcyclosiloxane for 14 days produced significant treatment-related increase in the liver weights of rats.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
PUB Date Free Form 1990
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A04/MF A04
Document Type NT
Control Number 028803040
Cataloging Source NTIS/MT
Origin NTIS
Type CAT