OLS : Record

RECORD NUMBER: 38 OF 2870

Main Title Acute Toxicity of Lead Particulates on Pulmonary Alveolar Macrophages: Ultrastructural and Microanalytical Studies.
Author deVries, C. R.; Ingram, P.; Walker, S. R.; Linton, R. W.; Gutknecht, W. F.;
CORP Author Duke Univ., Durham, NC. ;Veterans Administration Medical Center, Durham, NC. ;Research Triangle Inst., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83/323;
Stock Number PB86-144854
Subjects Lead poisoning; Toxicology; Lung; Reprints; Macrophages; Bioaccumulation
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB86-144854 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 11p
Abstract Although it is well established that respiratory uptake of lead-containing particles plays a substantial role in the epidemiology of plumbism, relatively little is known about the role of the pulmonary alveolar macrophage in lead poisoning. An in vitro system was designed to investigate the effects of lead oxide particles of respirable size on the rabbit alveolar macrophage. The studies were concerned with the intracellular solubility of PbO and Pb3O4 and changes in fine structure attributable to lead toxicity. The distribution of phagocytosed lead and its intracellular reprecipitation complexes was established by electron microprobe analysis and secondary ion mass spectroscopy in conjunction with transmission electron microscopy, scanning electron microscopy, scanning transmission electron microscopy, and backscatter imaging. It was found that Pb3O4,PbO and PbO-coated particles were ingested by the rabbit alveolar macrophages and that each of these lead oxide compounds produced similar damage to the fine structure of the cell. (Copyright (c) 1983 by the United States-Canadian Division of the International Academy of Pathology).
Supplementary Notes Prepared in cooperation with Veterans Administration Medical Center, Durham, NC., Research Triangle Inst., Research Triangle Park, NC., and North Carolina Univ. at Chapel Hill. Dept. of Chemistry. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
Availability Notes Pub. in Laboratory Investigation, v48 n1 p35-44 Jan 83.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute Toxicity of Lead Particulates on Pulmonary Alveolar Macrophages: Ultrastructural and Microanalytical Studies.
PUB Date Free Form c1983
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Control Number 608717184
Cataloging Source NTIS/MT
Origin NTIS
Type CAT