| Main Title |
Kinetochore-Staining of Spermatid Micronuclei: Studies of Mice Treated with X-Radiation or Acrylamide. |
| Author |
Collins, B. W.;
Howard, D. R.;
Allen, J. W.;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/193; |
| Stock Number |
PB92-188994 |
| Subjects |
X rays;
Acrylamides;
Spermatozoa;
Micronuclei;
Mice;
Fluorescent antibody technique;
Meiosis;
Staining;
Reprints;
Kinetochores
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB92-188994 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
08/22/1992 |
|
| Collation |
10p |
| Abstract |
The rodent spermatid micronucleus (MN) assay was used in conjunction with immunofluorescent techniques to distinguish kinetochores in MN following exposure of mice to X-radiation or acrylamide. After either treatment, modest increases in kinetochore-positive MN were observed. Spermatids which had been exposed during meiotic prophase to X-rays (400 cGy) had approximately 10-fold increases in MN compared to controls; up to 15% of the MN observed were kinetochore-positive. Following acrylamide treatment of meiotic prophase cells, there was a doubling of spermatid MN over baseline levels, approximately one-third of which were kinetochore-positive. (Copyright (c) 1992 Elsevier Science Publishers B.V.) |
| Supplementary Notes |
Pub. in Mutation Research, v281 n4 p287-294 1992. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Kinetochore-Staining of Spermatid Micronuclei: Studies of Mice Treated with X-Radiation or Acrylamide. |
| Category Codes |
57F; 57Y; 57V |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Control Number |
220521549 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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