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Main Title Kinetochore-Staining of Spermatid Micronuclei: Studies of Mice Treated with X-Radiation or Acrylamide.
Author Collins, B. W.; Howard, D. R.; Allen, J. W.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/193;
Stock Number PB92-188994
Subjects X rays; Acrylamides; Spermatozoa; Micronuclei; Mice; Fluorescent antibody technique; Meiosis; Staining; Reprints; Kinetochores
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB92-188994 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/22/1992
Collation 10p
Abstract The rodent spermatid micronucleus (MN) assay was used in conjunction with immunofluorescent techniques to distinguish kinetochores in MN following exposure of mice to X-radiation or acrylamide. After either treatment, modest increases in kinetochore-positive MN were observed. Spermatids which had been exposed during meiotic prophase to X-rays (400 cGy) had approximately 10-fold increases in MN compared to controls; up to 15% of the MN observed were kinetochore-positive. Following acrylamide treatment of meiotic prophase cells, there was a doubling of spermatid MN over baseline levels, approximately one-third of which were kinetochore-positive. (Copyright (c) 1992 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Mutation Research, v281 n4 p287-294 1992. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Kinetochore-Staining of Spermatid Micronuclei: Studies of Mice Treated with X-Radiation or Acrylamide.
Category Codes 57F; 57Y; 57V
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 220521549
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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