OLS : Record


Main Title Kepone-Induced Scoliosis and Its Histological Consequences in Fish.
Author Couch, John; Winstead, James; Goodman., Larry;
CORP Author Environmental Research Lab., Gulf Breeze, Fla.
Year Published 1977
Report Number EPA/600/J-77/077;
Stock Number PB-277 182
Subjects Fishes; Scoliosis; Insecticides; Pesticides; Toxicology; Toxic diseases; Chlorine organic compounds; Minnows; Nervous system; Pathology; Musculosketal disorders; Central nervous system; Histology; Aquatic animals; Experimental data; Reprints; Kepone; Laboratory tests
Library   Call Number Additional Info Location Date Modified
NTIS PB-277 182 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 4p
Abstract Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.
Supplementary Notes Revision of report dated 8 Mar 77. Pub. in Science, v197 p585-587, 5 Aug 77.
NTIS Title Notes Journal article (Final).
Title Annotations Reprint: Kepone-Induced Scoliosis and Its Histological Consequences in Fish.
PUB Date Free Form 13 Apr 77
Category Codes 6T; 6C; 57Y; 98F; 86O
NTIS Prices PC A02/MF A01
Primary Description 600/04
Document Type NT
Control Number 323733563
Cataloging Source NTIS/MT
Origin NTIS
Type CAT