| Main Title |
Metabolism of 2-chloro'u-ring-14c/toluene by Rats Dosed Intravenously. |
| CORP Author |
Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8335096 |
| Stock Number |
OTS0507459 |
| Subjects |
Toxicology;
Health effects;
2-chlorotoluene;
Pharmaco Kinetics;
Mammals;
Rats;
Parenteral;
Intravenous;
Toxic substances;
Laboratory animals;
CAS No 95-49-8
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
OTS0507459 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
03/10/2010 |
|
| Collation |
15p |
| Abstract |
The metabolism of 2-chlorotoluene was examined in 4 female rats (strain not reported) injected intravenously with a single 0.7 mg/kg dose of (U-ring-14C)2-chlorotoluene. Rats eliminated 69-81% and 14-18% of the applied dose in the urine and as expired volatiles, respectively, within 4 days after dosing. Nearly all of the volatile 14C in expired air was 2-chlorotoluene. The primary urinary metabolites were mercapturic acid, glucuronide, and 2- chlorohippurate, representing 22-24, 13-20, and 7-11% of urinary 14C, respectively. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Control Number |
028801220 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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